Journal article
In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide
Abstract
Existing oral or injectable antipsychotic drug delivery strategies typically demonstrate low bioavailability to targeted brain regions, incentivizing the development of alternative delivery strategies. Delivery via the nasal cavity circumvents multiple barriers for reaching the brain but requires drug delivery vehicles with very specific properties to be effective. Herein, we report in situ-gelling and degradable bulk nanoparticle network …
Authors
Majcher MJ; Babar A; Lofts A; Leung A; Li X; Abu-Hijleh F; Smeets NMB; Mishra RK; Hoare T
Journal
Journal of Controlled Release, Vol. 330, , pp. 738–752
Publisher
Elsevier
Publication Date
February 2021
DOI
10.1016/j.jconrel.2020.12.050
ISSN
0168-3659