Journal article
Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development
Abstract
The second messenger bis-3,5-cyclic di-guanosine monophosphate (c-di-GMP) determines when Streptomyces initiate sporulation. c-di-GMP signals are integrated into the genetic differentiation network by the regulator BldD and the sigma factor σWhiG . However, functions of the development-specific diguanylate cyclases (DGCs) CdgB and CdgC, and the c-di-GMP phosphodiesterases (PDEs) RmdA and RmdB, are poorly understood. Here, we provide biochemical …
Authors
Haist J; Neumann SA; Al‐Bassam MM; Lindenberg S; Elliot MA; Tschowri N
Journal
Molecular Microbiology, Vol. 114, No. 5, pp. 808–822
Publisher
Wiley
Publication Date
November 2020
DOI
10.1111/mmi.14581
ISSN
0950-382X