A novel candidate region for ALS on chromosome 14q11.2 Academic Article uri icon

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abstract

  • Sequence variations with biologic effect in ALS have been identified in the gene for vascular endothelial growth factor (VEGF). The gene for a related protein, angiogenin, lies on chromosome 14q11.2. Analysis of the angiogenin (ANG) gene in the authors' population has demonstrated a significant allelic association with the rs11701 single nucleotide polymorphism (SNP) and identified a novel mutation in two individuals with sporadic ALS that potentially inhibits angiogenin function. These observations propose a candidate region for ALS on chromosome 14q11.2 and suggest that other genes with similar function to VEGF may be important in the pathogenesis of ALS.

authors

  • Greenway, Matthew
  • Alexander, MD
  • Ennis, S
  • Traynor, BJ
  • Corr, B
  • Frost, E
  • Green, A
  • Hardiman, O

publication date

  • November 23, 2004

has subject area