Journal article
Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2
Abstract
The stem cell-intrinsic model of self-renewal via asymmetric cell division (ACD) posits that fate determinants be partitioned unequally between daughter cells to either activate or suppress the stemness state. ACD is a purported mechanism by which hematopoietic stem cells (HSCs) self-renew, but definitive evidence for this cellular process remains open to conjecture. To address this issue, we chose 73 candidate genes that function within the …
Authors
Ting SB; Deneault E; Hope K; Cellot S; Chagraoui J; Mayotte N; Dorn JF; Laverdure J-P; Harvey M; Hawkins ED
Journal
Blood, Vol. 119, No. 11, pp. 2510–2522
Publisher
American Society of Hematology
Publication Date
March 15, 2012
DOI
10.1182/blood-2011-11-393272
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Protein Complex 2Adaptor Protein Complex alpha SubunitsAnimalsAsymmetric Cell DivisionBiomarkersBlotting, WesternCell DifferentiationCell LineageCell PolarityCell ProliferationEndocytosisFlow CytometryGene Expression ProfilingHematopoietic Stem Cell TransplantationHematopoietic Stem CellsLeukemiaMiceNeoplastic Stem CellsOligonucleotide Array Sequence AnalysisRNA, MessengerReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionStem Cells