Kristin Hope - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Member, McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences
Associate Professor (Part-Time), Biochemistry & Biomedical Sciences, Faculty of Health Sciences

Scholarly Activity in McMaster Experts

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conferences
- Aberrant Splicing of MBD1 Reshapes the Epigenome to Drive Convergent Myeloerythroid Defects in MDS. Blood. 317-317. 2023
- Identifying Stress Granules As Determinants of Leukemia Stem Cell Maintenance and Stress Adaptation. Blood. 405-405. 2023
- PLAGL2 Independently Drives Aberrant Erythropoiesis and Initiation of Preleukemic State. Blood. 3663-3663. 2021
- Inhibiting Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) Induces Selective Leukemia Cell Death. Blood. 3922-3922. 2019
- The Splicing Factor RBM17 Supports Leukemia Stem Cell Self-Renewal. Blood. 1238-1238. 2019
- OTUD7A regulates neurodevelopmental phenotypes in the 15q13.3 microdeletion syndrome. European Journal of Human Genetics. 840-841. 2019
- MUSAShi-1 IS A MASTER REGULATOR OF ABERRANT TRANSLATION IN GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology. 112-112. 2019
- INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN, MUSASHI 1 IN PEDIATRIC GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology. 133-133. 2018
- INVESTIGATING THE ROLE OF THE RNA BINDING PROTEIN, MUSASHI, IN GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology. 43-43. 2017
- PLAG1 and USF2 Regulate Primitive Hematopoietic Expression of Musashi-2. Blood. 2015
- Musashi-2 postranscriptionally attenuates aryl hydrocarbon receptor signaling to expand human hematopoietic stem cells. Experimental Hematology. S90-S90. 2015
- Unraveling the importance of the post-transcriptional RNA regulon in leukemic stem cells by in vivo RNAi. Experimental Hematology. S59-S59. 2015
- A Functional In Vivo RNAi screen Involving Jumonji C Domain Containing Candidates Unravels Kdm5b As a Negative Modulator of Hematopoietic Stem Cell Self-Renewal. Blood. 178-178. 2011
- Enriched MicroRNA-126 Bioactivity Marks the Primitive Compartment In AML and Regulates LSC Numbers. Blood. 94-94. 2010
- Gpx3 Determines Competitiveness of Normal and Leukemic Stem Cells. Blood. 670-671. 2010
- An RNA Interference Screen Identifies the Cell Fate Determinants Msi2 and Prox1 as Novel Regulators of Hematopoietic Stem Cell Self-Renewal. Blood. 164-164. 2009
- Histone Demethylases as Modulators of Hematopoietic Cell Fate. Blood. 163-164. 2009
- An RNA Interference Screen Reveals Fate Determinants Implicated in Asymmetric Cell Division as Potential Regulators of Hematopoietic Stem Cell Self-Renewal.. Blood. 855-855. 2008
- MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis.. Blood. 466-466. 2005
- Selective eradication of acute myeloid leukemia stem cells using an antibody that ligates the CD44 adhesion molecule. Blood Cells, Molecules, and Diseases. 109-109. 2004
- Selective eradication of acute myeloid leukemia stem cells using an antibody that ligates the CD44 adhesion molecule.. Blood. 620A-621A. 2003
journal articles
- Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia.. Blood. 144:2018-2032. 2024
- Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.. Science Translational Medicine. 16:eadn1285. 2024
- 1011 – UNCOVERING CONVERGENT ABERRANT SPLICING EVENTS DRIVING MYELODYSPLASTIC SYNDROME DEFECTS. Experimental Hematology. 137:104312. 2024
- 3171 – IDENTIFYING STRESS GRANULES AS DETERMINANTS OF LEUKEMIA STEM CELL MAINTENANCE AND STRESS ADAPTATION. Experimental Hematology. 137:104491. 2024
- RNA binding protein-directed control of leukemic stem cell evolution and function.. HemaSphere. 8:e116. 2024
- Decoding the Epigenetic Drivers of Menin-MLL Inhibitor Resistance in KMT2A-Rearranged Acute Myeloid Leukemia. Blood. 142:587. 2023
- In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target. Blood Cancer Discov. 4:180-207. 2023
- Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature Communications. 14:136. 2023
- Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature Communications. 13:7506. 2022
- Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia. Molecular Cancer Research. 20:1659-1673. 2022
- PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal. Blood. 140:992-1008. 2022
- The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors. Nature Communications. 13:3833. 2022
- Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes. Cell Reports. 39:110947-110947. 2022
- Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence. Science Advances. 7:eabi5568. 2021
- Inhibiting Mitochondrial Complex II Exposes a Novel Metabolic Vulnerability in Acute Myeloid Leukemia. Blood. 138:1300. 2021
- C.5 Musashi-1 is a master regulator of aberrant translation in MYC-amplified Group 3 medulloblastoma. Canadian Journal of Neurological Sciences. 48:S19-S19. 2021
- Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis. Blood Advances. 5:3120-3133. 2021
- 3138 – A TWO-STEP IN VIVO CRISPR SCREEN UNVEILS PERVASIVE RNA-BINDING PROTEIN DEPENDENCIES FOR LEUKEMIC STEM CELLS AND IDENTIFIES ELAVL1 AS A THERAPEUTIC TARGET. Experimental Hematology. 100:s109. 2021
- Very long chain fatty acid metabolism is required in acute myeloid leukemia. Blood. 137:3518-3532. 2021
- MBRS-01. DISSECTING REGULATORS OF THE ABERRANT POST-TRANSCRIPTIONAL LANDSCAPE IN MYC-AMPLIFIED GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology. 22:iii399-iii399. 2020
- Assessing the Safety of a Cell-Based Immunotherapy for Brain Cancers Using a Humanized Model of Hematopoiesis. STAR Protocols. 1:100124-100124. 2020
- Making a bet on RET for hematopoietic stem cell expansion. Blood. 136:2484-2486. 2020
- Hematopoiesis in High Definition: Combining State and Fate Mapping. Cell Stem Cell. 27:354-355. 2020
- 3060 – DOWNREGULATED STAUFEN1 COMPROMISES HEMATOPOIETIC STEM CELL ACTIVITY IN VIVO AND ELICITS EXPRESSION SIGNATURES CHARACTERISTIC OF CLINICAL ANEMIAS. Experimental Hematology. 88:S56-S56. 2020
- The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma. Cell Stem Cell. 26:832-844.e6. 2020
- Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance. Cancer Research. 79:5799-5811. 2019
- Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque. Molecular Therapy. 27:1074-1086. 2019
- MEDU-44. MUSASHI-1 IS A MASTER REGULATOR OF ABERRANT TRANSLATION IN GROUP 3 MEDULLOBLASTOMA. Neuro-Oncology. 21:ii112-ii113. 2019
- Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control. Biochemistry and Cell Biology. 97:10-20. 2019
- 2002 The Mitotic Spindle Orientation Factor Lfc/Arhgef2 is Essential for Hematopoietic Stem Cell Function. Experimental Hematology. 64:s41. 2018
- PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 10:1384-1397. 2018
- OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome. American Journal of Human Genetics. 102:278-295. 2018
- DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Cell Reports. 17:1892-1904. 2016
- Producing megakaryocytes from a human peripheral blood source. Transfusion. 56:1066-1074. 2016
- Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells. Nature. 532:508-511. 2016
- RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity. Blood. 122:1545-1555. 2013
- Cancer Stem Cells: Prospective Isolation and Progress Toward Functional Biomarker Identification. Current Pathobiology Reports. 1:81-90. 2013
- A role for GPx3 in activity of normal and leukemia stem cells. Journal of Experimental Medicine (JEM). 209:895-901. 2012
- Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. Blood. 119:2510-2522. 2012
- A Functional In Vivo RNAi screen Involving Jumonji C Domain Containing Candidates Unravels Kdm5b As a Negative Modulator of Hematopoietic Stem Cell Self-Renewal. Blood. 118:385. 2011
- Roles for MSI2 and PROX1 in hematopoietic stem cell activity. Current Opinion in Hematology. 18:203-207. 2011
- Clonal interrogation of stem cells. Nature Methods. 8:S36-S40. 2011
- RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity. Blood. 117:e27-e38. 2011
- Gpx3 Determines Competitiveness of Normal and Leukemic Stem Cells.. Blood. 116:1587. 2010
- An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity. Cell Stem Cell. 7:101-113. 2010
- An RNA Interference Screen Identifies the Cell Fate Determinants Msi2 and Prox1 as Novel Regulators of Hematopoietic Stem Cell Self-Renewal.. Blood. 114:394. 2009
- Histone Demethylases as Modulators of Hematopoietic Cell Fate.. Blood. 114:393. 2009
- An RNA Interference Screen Reveals Fate Determinants Implicated in Asymmetric Cell Division as Potential Regulators of Hematopoietic Stem Cell Self-Renewal. Blood. 112:2462. 2008
- High Levels of MicroRNA-126 Bioactivity Specify the LSC Compartment in AML. Blood. 112:510. 2008
- Modeling the Initiation and Progression of Human Acute Leukemia in Mice. Science. 316:600-604. 2007
- Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nature Medicine. 12:1167-1174. 2006
- Nuclear localizing sequences promote nuclear translocation and enhance the radiotoxicity of the anti-CD33 monoclonal antibody HuM195 labeled with 111In in human myeloid leukemia cells.. Journal of Nuclear Medicine. 47:827-836. 2006
- Concepts of human leukemic development. Oncogene. 23:7164-7177. 2004
- Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nature Immunology. 5:738-743. 2004
- Human acute myeloid leukemia stem cells. Archives of Medical Research. 34:507-514. 2003
preprints