Journal article
Formation and excision of nitrofuran-DNA adducts in Escherichia coli
Abstract
When Escherichia coli were incubated with the strong mutagen 2[14C]2-amino-4-(5-nitro-2 furyl)-thiazole (ANFT) radioactivity became tightly and presumably covalently bound to DNA. Hydrolysis of the DNA with nucleases yielded low molecular weight radioactive material. The bound radioactivity was associated with at least two functionally and chemically distinct adducts. One of these was rapidly removed in uvr+ E. coli while the other was more …
Authors
Wentzell B; McCalla DR
Journal
Chemico-Biological Interactions, Vol. 31, No. 2, pp. 133–150
Publisher
Elsevier
Publication Date
8 1980
DOI
10.1016/0009-2797(80)90001-0
ISSN
0009-2797