Journal article
CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine–Induced T Cells to Both the Lung Parenchyma and Airway
Abstract
Although most novel tuberculosis (TB) vaccines are designed for delivery via the muscle or skin for enhanced protection in the lung, it has remained poorly understood whether systemic vaccine-induced memory T cells can readily home to the lung mucosa prior to and shortly after pathogen exposure. We have investigated this issue by using a model of parenteral TB immunization and intravascular immunostaining. We find that systemically induced …
Authors
Jeyanathan M; Afkhami S; Khera A; Mandur T; Damjanovic D; Yao Y; Lai R; Haddadi S; Dvorkin-Gheva A; Jordana M
Journal
The Journal of Immunology, Vol. 199, No. 7, pp. 2555–2569
Publisher
Oxford University Press (OUP)
Publication Date
October 1, 2017
DOI
10.4049/jimmunol.1700382
ISSN
0022-1767