selected scholarly activity
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chapters
- Chapter 66 Filling the Immunological Gap Recombinant Viral Vectors for Mucosal Vaccines. 1291-1306. 2015
- Filling the Immunological Gap. 1291-1306. 2015
- Immunization Strategies Against Pulmonary Tuberculosis: Considerations of T Cell Geography. Advances in Experimental Medicine and Biology. 267-278. 2013
- Respiratory Mucosal Immunization against Pulmonary Tuberculosis. 307-326. 2010
- Chapter 29 Growth Factors. 353-361. 2009
- Growth Factors. 353-361. 2009
- Growth factors. 353-361. 2008
- Use of gene transfer to study lung: Cytokine biology. 171-191. 2002
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conferences
- Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity. European Journal of Immunology. 714-714. 2019
- IN VITRO EVALUATION OF THE AEROGEN MICROPUMP AEROSOL DELIVERY SYSTEM FOR DELIVERING ADHU5AG85A TB VACCINE TO HUMAN SUBJECTS. Journal of Aerosol Medicine and Pulmonary Drug Delivery. A12-A12. 2015
- In Vitro Evaluation Of The Aerogen Micropump Aerosol Delivery System For Delivering Adhu5ag85a Tb Vaccine To Human Subjects. American Journal of Respiratory and Critical Care Medicine. 2015
- Targeted PGE2 inhibition enhances anti-viral immunity through induction of Type I interferon in macrophages. Journal of Immunology. 2013
- Alveolar macrophages control the quality of CD4+T lymphocytes in the respiratory tract upon recombinant adenoviral mucosal vaccination. Journal of Immunology. 2009
- 128 Oncostatin M-receptor Deficient Phenotype Provides Evidence that Oncostatin M is Critical for IL-4-induced Eosinophil Accumulation in Lungs In Vivo. Cytokine. 35-35. 2007
- T cell geography determines protective efficacy of genetic-based tuberculosis immunization at the respiratory mucosa. Immunology. 24-24. 2007
- Use of recombinant virus-vectored tuberculosis vaccines for respiratory mucosal immunization. Tuberculosis. 211-217. 2006
- Isolation and transduction of monocytes: promising vehicles for therapeutic arteriogenesis. Langenbeck's Archives of Surgery. 72-82. 2006
- Manipulation of dendritic cells for host defence against intracellular infections. Biochemical Society Transactions. 283-286. 2006
- The antimicrobial/neutrophil elastase inhibitor elafin is a type 1 mucosal adjuvant which regulates dendritic cells and adaptive immunity in the lung. Immunology. 29-30. 2005
- Differential regulation of expression of DAP12 and its associating molecules during mycobacterial infection. The FASEB Journal. C171-C171. 2003
- IL-4 cytokine gene transfer promotes anti-CD45RB induced long-term survival of islet xenografts. Xenotransplantation. 114-114. 2001
- DIFFERENTIAL EFFECTS OF DENDRITIC CELLS OVEREXPRESSING MAMMALIAN IL-10 ON ORGAN ALLOGRAFT AND ANTI-TUMOR IMMUNITY. Transplantation. S248-S248. 1999
- Type 1 cytokine production by macrophages during pulmonary mycobacterial infection: Requirement of IL-12 for the release of IFN gamma but not TNF alpha.. American Journal of Respiratory and Critical Care Medicine. A752-A752. 1999
- Transforming Growth Factor-β Gene Transfer to the Lung Induces Myofibroblast Presence and Pulmonary Fibrosis. Current topics in pathology. 35-45. 1999
- Adenovirus-Mediated Gene Transfer of the Proteoglycan Biglycan Induces Fibroblastic Responses in the Lung. Chest. 137S-137S. 1997
- In Vivo Adenovirus-Mediated Expression of Human Pre-Elafin, a Potent Neutrophil Elastase Inhibitor. Chest. 128S-129S. 1997
- Adenovirus‐Vector‐Mediated Cytokine Gene Transfer to Lung Tissuea. Annals of the New York Academy of Sciences. 235-244. 1996
- Adenovirus Vectors for Cytokine Gene Expression. Annals of the New York Academy of Sciences. 282-293. 1995
- ADENOVIRUS VECTOR CYTOKINE GENE-TRANSFER TO LUNG-TISSUE. Journal of Cellular Biochemistry. 377-377. 1995
- ADENOVIRUS VECTOR CYTOKINE GENE-TRANSFER TO LUNG-TISSUE. The FASEB Journal. A858-A858. 1995
- ONCOSTATIN-M INHIBITS NEUTROPHIL INFLUX IN LPS-INDUCED ACUTE LUNG INFLAMMATION IN SPRAGUE-DAWLEY RATS. The FASEB Journal. A492-A492. 1995
- Cytokine regulation of hepatic acute phase protein expression. CYTOKINES AND THE LIVER. 164-171. 1995
- DETECTION OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND MACROPHAGE INFLAMMATORY PEPTIDE-2 (MIP-2) IN THE LUNG OF RATS EXPOSED TO A SINGLE INTRATRACHEAL INSTILLATION OF LIPOPOLYSACCHARIDE (LPS). American Review of Respiratory Disease. A730-A730. 1993
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journal articles
- A next-generation inhalable dry powder COVID vaccine. Nature. 624:532-534. 2023
- Viral-vectored respiratory mucosal vaccine strategies. Current Opinion in Immunology. 84:102370-102370. 2023
- Adenoviral-vectored next-generation respiratory mucosal vaccines against COVID-19. Current Opinion in Virology. 61:101334-101334. 2023
- Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung. EMBO Molecular Medicine. 15:e17084. 2023
- The knowledge-informed development of inhaled aerosol vaccine strategies. University of Toronto Medical Journal. 100:27-28. 2023
- Author Correction: Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis. Nature Immunology. 24:1049-1049. 2023
- Internal microstructure of spray dried particles affects viral vector activity in dry vaccines. International Journal of Pharmaceutics. 640:122988-122988. 2023
- Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice. Pharmaceutical Research. 40:1165-1176. 2023
- Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice. npj Vaccines. 8:25. 2023
- Corrigendum: Differential biodistribution of adenoviral-vectored vaccine following intranasal and endotracheal deliveries leads to different immune outcomes. Frontiers in Immunology. 14:1151809. 2023
- Corrigendum to “Screening amino acid additives as aerosolization modifiers for spray dried inhalable viral-vectored vaccines” [J. Drug Discov. Sci. Technol. 76 (2022) 1773–2247/103815]. Journal of Drug Delivery Science and Technology. 78:103926-103926. 2022
- Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis. Nature Immunology. 23:1687-1702. 2022
- Screening amino acid additives as aerosolization modifiers for spray dried inhalable viral-vectored vaccines. Journal of Drug Delivery Science and Technology. 76:103815-103815. 2022
- Dextran Mass Ratio Controls Particle Drying Dynamics in a Thermally Stable Dry Powder Vaccine for Pulmonary Delivery. Pharmaceutical Research. 39:2315-2328. 2022
- Protocol for isolation and characterization of lung tissue resident memory T cells and airway trained innate immunity after intranasal vaccination in mice. STAR Protocols. 3:101652-101652. 2022
- Comparing Current and Next-Generation Humanized Mouse Models for Advancing HIV and HIV/Mtb Co-Infection Studies. Viruses. 14:1927-1927. 2022
- Cryoprotective agents influence viral dosage and thermal stability of inhalable dry powder vaccines. International Journal of Pharmaceutics. 617:121602-121602. 2022
- Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell. 185:896-915.e19. 2022
- Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans. JCI insight. 7:e155655. 2022
- Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes. Frontiers in Immunology. 13:860399. 2022
- Validation of a diffusion-based single droplet drying model for encapsulation of a viral-vectored vaccine using an acoustic levitator. International Journal of Pharmaceutics. 605:120806-120806. 2021
- COVID-19 vaccines and kidney disease. Nature Reviews Nephrology. 17:291-293. 2021
- COVID‐19: Current knowledge in clinical features, immunological responses, and vaccine development. The FASEB Journal. 35:e21409. 2021
- Airway Macrophages Mediate Mucosal Vaccine–Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection. Journal of Immunology. 205:2750-2762. 2020
- Immunological considerations for COVID-19 vaccine strategies. Nature Reviews Immunology. 20:615-632. 2020
- Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies. Journal of Leukocyte Biology. 108:825-834. 2020
- Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo. Scientific Reports. 10:13349. 2020
- Effect of Shear Stresses on Adenovirus Activity and Aggregation during Atomization To Produce Thermally Stable Vaccines by Spray Drying. ACS Biomaterial Science and Engineering. 6:4304-4313. 2020
- Advancing Immunotherapeutic Vaccine Strategies Against Pulmonary Tuberculosis. Frontiers in Immunology. 11:557809. 2020
- Assessment of Immune Protective T Cell Repertoire in Humans Immunized with Novel Tuberculosis Vaccines. Methods in molecular biology (Clifton, N.J.). 2111:175-192. 2020
- Evaluating the sensitivity of the bovine BCG challenge model using a prime boost Ad85A vaccine regimen. Vaccine. 38:1241-1248. 2020
- Stabilization of HSV-2 viral vaccine candidate by spray drying. International Journal of Pharmaceutics. 569:118615-118615. 2019
- Single-Dose Mucosal Immunotherapy With Chimpanzee Adenovirus-Based Vaccine Accelerates Tuberculosis Disease Control and Limits Its Rebound After Antibiotic Cessation. Journal of Infectious Diseases. 220:1355-1366. 2019
- Acoustic levitation as a screening method for excipient selection in the development of dry powder vaccines. International Journal of Pharmaceutics. 563:71-78. 2019
- Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders. International Journal of Pharmaceutics. 561:66-73. 2019
- Immunotherapeutic effects of recombinant adenovirus encoding interleukin 12 in experimental pulmonary tuberculosis. Scandinavian Journal of Immunology. 89:e12743. 2019
- Mucosal-Pull Induction of Lung-Resident Memory CD8 T Cells in Parenteral TB Vaccine-Primed Hosts Requires Cognate Antigens and CD4 T Cells. Frontiers in Immunology. 10:2075. 2019
- Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity. Cell. 175:1634-1650.e17. 2018
- Consecutive Spray Drying to Produce Coated Dry Powder Vaccines Suitable for Oral Administration. ACS Biomaterial Science and Engineering. 4:1669-1678. 2018
- New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity. Trends in Immunology. 39:419-433. 2018
- CD11b+ Dendritic Cell–Mediated Anti–Mycobacterium tuberculosis Th1 Activation Is Counterregulated by CD103+ Dendritic Cells via IL-10. Journal of Immunology. 200:1746-1760. 2018
- Pseudomonas aeruginosaLasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway. Thorax. 73:49-61. 2018
- CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine–Induced T Cells to Both the Lung Parenchyma and Airway. Journal of Immunology. 199:2555-2569. 2017
- Expression and role of VLA-1 in resident memory CD8 T cell responses to respiratory mucosal viral-vectored immunization against tuberculosis. Scientific Reports. 7:9525. 2017
- Enhancement of Antituberculosis Immunity in a Humanized Model System by a Novel Virus-Vectored Respiratory Mucosal Vaccine. Journal of Infectious Diseases. 216:135-145. 2017
- Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo. Vaccine. 35:2916-2924. 2017
- Lung Mucosal Immunity & Mucosal TB Vaccination Strategies for Human Application. Journal of Pharmacy and Pharmaceutical Sciences. 20:13S-13S. 2017
- Induction of an Immune-Protective T-Cell Repertoire With Diverse Genetic Coverage by a Novel Viral-Vectored Tuberculosis Vaccine in Humans. Journal of Infectious Diseases. 214:1996-2005. 2016
- Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines. Cellular Immunology. 310:53-62. 2016
- Optimization of Spray Drying Conditions for Yield, Particle Size and Biological Activity of Thermally Stable Viral Vectors. Pharmaceutical Research. 33:2763-2776. 2016
- Efficacy of gene-therapy based on adenovirus encoding granulocyte-macrophage colony-stimulating factor in drug-sensitive and drug-resistant experimental pulmonary tuberculosis. Tuberculosis. 100:5-14. 2016
- Correction: Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. PLoS Pathogens. 12:e1005706-e1005706. 2016
- Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying. International Journal of Pharmaceutics. 506:289-301. 2016
- Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway. PLoS Pathogens. 12:e1005589-e1005589. 2016
- Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens. Molecular Therapy - Methods and Clinical Development. 3:16030-16030. 2016
- TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS Pathogens. 12:e1005368-e1005368. 2016
- Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection. Mucosal Immunology. 8:1373-1387. 2015
- Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis. Journal of Immunology. 195:2900-2907. 2015
- Developing aerosol vaccines for Mycobacterium tuberculosis: Workshop proceedings. Vaccine. 33:3038-3046. 2015
- Mucosal immunity and novel tuberculosis vaccine strategies: route of immunisation-determined T-cell homing to restricted lung mucosal compartments. European Respiratory Review. 24:356-360. 2015
- AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates. PLoS ONE. 10:e0135009-e0135009. 2015
- Age at Mycobacterium bovis BCG Priming Has Limited Impact on Anti-Tuberculosis Immunity Boosted by Respiratory Mucosal AdHu5Ag85A Immunization in a Murine Model. PLoS ONE. 10:e0131175-e0131175. 2015
- Protection Induced by Simultaneous Subcutaneous and Endobronchial Vaccination with BCG/BCG and BCG/Adenovirus Expressing Antigen 85A against Mycobacterium bovis in Cattle. PLoS ONE. 10:e0142270-e0142270. 2015
- New Approaches to TB Vaccination. Chest. 146:804-812. 2014
- Human type 5 adenovirus-based tuberculosis vaccine: is the respiratory route of delivery the future?. Expert Review of Vaccines. 13:927-930. 2014
- Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells. Mucosal Immunology. 7:670-683. 2014
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Restoration of innate immune activation accelerates
T h1‐cell priming and protection following pulmonary mycobacterial infection. European Journal of Immunology. 44:1375-1386. 2014 - Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages. Immunity. 40:554-568. 2014
- Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines. Vaccine. 32:1304-1310. 2014
- Type 1 interferon gene transfer enhances host defense against pulmonary Streptococcus pneumoniae infection via activating innate leukocytes. Molecular Therapy - Methods and Clinical Development. 1:5-5. 2014
- A Human Type 5 Adenovirus–Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity. Science Translational Medicine. 5:205ra134. 2013
- Marked Improvement of Severe Lung Immunopathology by Influenza-Associated Pneumococcal Superinfection Requires the Control of Both Bacterial Replication and Host Immune Responses. American Journal of Pathology. 183:868-880. 2013
- Pulmonary Expression of Oncostatin M (OSM) Promotes Inducible BALT Formation Independently of IL-6, Despite a Role for IL-6 in OSM-Driven Pulmonary Inflammation. Journal of Immunology. 191:1453-1464. 2013
- Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity. Mucosal Immunology. 6:612-625. 2013
- Identification of Synthetic Peptides that Inhibit Lipopolysaccharide (LPS) Binding to Myeloid Differentiation Protein-2 (MD-2). Journal of immunotherapy (Hagerstown, Md. : 1997). 36:197-207. 2013
- Immunotherapeutic effects of recombinant adenovirus encoding granulocyte–macrophage colony-stimulating factor in experimental pulmonary tuberculosis. Clinical and Experimental Immunology. 171:283-297. 2013
- Continuous and Discontinuous Cigarette Smoke Exposure Differentially Affects Protective Th1 Immunity against Pulmonary Tuberculosis. PLoS ONE. 8:e59185-e59185. 2013
- Corrigendum to “Immunopathology in influenza virus infection: Uncoupling the friend from foe” [Clin. Immunol. 144 (2012) 57–69]. Clinical Immunology. 146:70-70. 2013
- Within the Enemy’s Camp: contribution of the granuloma to the dissemination, persistence and transmission of Mycobacterium tuberculosis. Frontiers in Immunology. 4:30. 2013
- Global Gene Transcriptome Analysis in Vaccinated Cattle Revealed a Dominant Role of IL-22 for Protection against Bovine Tuberculosis. PLoS Pathogens. 8:e1003077-e1003077. 2012
- Goats Primed with Mycobacterium bovis BCG and Boosted with a Recombinant Adenovirus Expressing Ag85A Show Enhanced Protection against Tuberculosis. Clinical and Vaccine Immunology. 19:1339-1347. 2012
- Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A. Vaccine. 30:6294-6300. 2012
- Immunopathology in influenza virus infection: Uncoupling the friend from foe. Clinical Immunology. 144:57-69. 2012
- Mechanisms of delayed anti-tuberculosis protection in the lung of parenteral BCG-vaccinated hosts: A critical role of airway luminal T cells. Mucosal Immunology. 5:420-431. 2012
- A novel genetically engineeredMycobacterium smegmatis-based vaccine promotes anti-TB immunity. Expert Review of Vaccines. 11:35-38. 2012
- Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection. Vaccine. 30:350-360. 2012
- Regulation of TB Vaccine-Induced Airway Luminal T Cells by Respiratory Exposure to Endotoxin. PLoS ONE. 7:e41666-e41666. 2012
- Understanding Delayed T-Cell Priming, Lung Recruitment, and Airway Luminal T-Cell Responses in Host Defense against Pulmonary Tuberculosis. Journal of Immunology Research. 2012:1-13. 2012
- Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection. American Journal of Pathology. 179:2963-2976. 2011
- FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice. Antiviral Research. 92:346-355. 2011
- Control of Pathogenic CD4 T Cells and Lethal Immunopathology by Signaling Immunoadaptor DAP12 during Influenza Infection. Journal of Immunology. 187:4280-4292. 2011
- Interferon-λ Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell–Mediated Inflammation in Mouse Intestine. Gastroenterology. 141:249-258.e2. 2011
- Intestinal epithelial cell-derived integrin αβ6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response. Journal of Leukocyte Biology. 90:751-759. 2011
- Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis. Infection and Immunity. 79:2134-2134. 2011
- Pulmonary mycobacterial granuloma increased IL-10 production contributes to establishing a symbiotic host-microbe microenvironment. - PubMed - NCBI. American Journal of Pathology. 178:1622-1634. 2011
- Pulmonary mucosal dendritic cells in T-cell activation: implications for TB therapy. Expert Review of Respiratory Medicine. 5:75-85. 2011
- CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells. Blood. 117:1146-1155. 2011
- Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) Modulates Immune Responses toAspergillus fumigatusDuring Fungal Asthma in Mice. Immunological Investigations. 40:692-722. 2011
- Respiratory mucosal immunization with adenovirus gene transfer vector induces helper CD4 T cell‐independent protective immunity. Journal of Gene Medicine. 12:693-704. 2010
- Airway luminal T cells: A newcomer on the stage of TB vaccination strategies. Trends in Immunology. 31:247-252. 2010
- Murine Airway Luminal Antituberculosis Memory CD8 T Cells by Mucosal Immunization Are Maintained Via Antigen-Driven In Situ Proliferation, Independent of Peripheral T Cell Recruitment. American Journal of Respiratory and Critical Care Medicine. 181:862-872. 2010
- Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung. Journal of Immunology. 184:2048-2056. 2010
- Importance of T-cell location rekindled: implication for tuberculosis vaccination strategies. Expert Review of Vaccines. 8:1465-1468. 2009
- Influence of the Tissue Microenvironment on Toll-Like Receptor Expression by CD11c+Antigen-Presenting Cells Isolated from Mucosal Tissues. Clinical and Vaccine Immunology. 16:1615-1623. 2009
- Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis. Infection and Immunity. 77:3364-3373. 2009
- Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis. PLoS ONE. 4:e5856-e5856. 2009
- Immunization With a Bivalent Adenovirus-vectored Tuberculosis Vaccine Provides Markedly Improved Protection Over Its Monovalent Counterpart Against Pulmonary Tuberculosis. Molecular Therapy. 17:1093-1100. 2009
- CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cells. BMC Immunology. 9:48. 2008
- Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector. Genetic Vaccines and Therapy. 6:5. 2008
- Airway Delivery of Soluble Mycobacterial Antigens Restores Protective Mucosal Immunity by Single Intramuscular Plasmid DNA Tuberculosis Vaccination: Role of Proinflammatory Signals in the Lung. Journal of Immunology. 181:5618-5626. 2008
- Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes. Journal of Immunology. 181:2428-2437. 2008
- Mucosally Delivered Dendritic Cells Activate T Cells Independently of IL-12 and Endogenous APCs. Journal of Immunology. 181:2356-2367. 2008
- Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategy in a dendritic cell–induced peanut allergy model. Journal of Allergy and Clinical Immunology. 122:55-61.e7. 2008
- Heterologous Boosting of Recombinant Adenoviral Prime Immunization With a Novel Vesicular Stomatitis Virus–vectored Tuberculosis Vaccine. Molecular Therapy. 16:1161-1169. 2008
- NK Cells Play a Critical Protective Role in Host Defense against Acute ExtracellularStaphylococcus aureusBacterial Infection in the Lung. Journal of Immunology. 180:5558-5568. 2008
- Heterologous boost vaccines for bacillus Calmette-Guerin prime immunization against tuberculosis (vol 6, pg 539, 2007). Expert Review of Vaccines. 7:274-274. 2008
- Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells. Molecular Therapy. 16:411-418. 2008
- Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells.. Molecular Therapy. 16:411-418. 2008
- TIM-4 Expressed by Mucosal Dendritic Cells Plays a Critical Role in Food Antigen–Specific Th2 Differentiation and Intestinal Allergy. Gastroenterology. 133:1522-1533. 2007
- Critical Negative Regulation of Type 1 T Cell Immunity and Immunopathology by Signaling Adaptor DAP12 during Intracellular Infection. Journal of Immunology. 179:4015-4026. 2007
- Critical negative regulation of immunopathology by signaling intracellular infection. Journal of Immunology. 179:4015-4026. 2007
- Heterologous boost vaccines for bacillus Calmette-Guérin prime immunization against tuberculosis.. Expert Review of Vaccines. 6:539-546. 2007
- Heterologous boost vaccines for bacillus Calmette–Guérin prime immunization against tuberculosis. Expert Review of Vaccines. 6:539-546. 2007
- Dendritic Cells Derived from Murine Colonic Mucosa Have Unique Functional and Phenotypic Characteristics. Journal of Immunology. 178:7984-7993. 2007
- Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during PulmonaryMycobacterium bovisBCG Infection. Infection and Immunity. 75:2244-2252. 2007
- On the Role of CD4+ T Cells in the CD8+ T-Cell Response Elicited by Recombinant Adenovirus Vaccines. Molecular Therapy. 15:997-1006. 2007
- On the role of CD4(+) T cells in the CD8(+) T-cell response elicited by recombinant adenovirus vaccines. Molecular Therapy. 15:997-1006. 2007
- Impact of IL-10 on Diaphragmatic Cytokine Expression and Contractility duringPseudomonasInfection. American Journal of Respiratory Cell and Molecular Biology. 36:504-512. 2007
- Mucosal Luminal Manipulation of T Cell Geography Switches on Protective Efficacy by Otherwise Ineffective Parenteral Genetic Immunization. Journal of Immunology. 178:2387-2395. 2007
- Intramuscular immunization with a monogenic plasmid DNA tuberculosis vaccine: Enhanced immunogenicity by electroporation and co-expression of GM-CSF transgene. Vaccine. 25:1342-1352. 2007
- Intranasal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances Protection by Parenteral Mycobacterium bovis BCG Immunization against Pulmonary Tuberculosis. Infection and Immunity. 74:4634-4643. 2006
- The Antimicrobial/Elastase Inhibitor Elafin Regulates Lung Dendritic Cells and Adaptive Immunity. American Journal of Respiratory Cell and Molecular Biology. 34:634-642. 2006
- Development of Cell-Based Tuberculosis Vaccines: Genetically Modified Dendritic Cell Vaccine Is a Much More Potent Activator of CD4 and CD8 T Cells Than Peptide- or Protein-Loaded Counterparts. Molecular Therapy. 13:766-775. 2006
- Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85A and Mycobacterium bovis BCG. Infection and Immunity. 74:1416-1418. 2006
- Intrapulmonary, Adenovirus-Mediated Overexpression of KARAP/DAP12 Enhances Fungal Clearance during Invasive Aspergillosis. Infection and Immunity. 73:8402-8406. 2005
- Role of Eotaxin-1 (CCL11) and CC Chemokine Receptor 3 (CCR3) in Bleomycin-Induced Lung Injury and Fibrosis. American Journal of Pathology. 167:1485-1496. 2005
- Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines. Current Gene Therapy. 5:485-492. 2005
- Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen. Journal of Immunology. 174:7986-7994. 2005
- Adenoviral Vectors for Mucosal Vaccination Against Infectious Diseases. Viral Immunology. 18:283-291. 2005
- Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. American Journal of Physiology - Lung Cellular and Molecular Physiology. 288:L841-L848. 2005
- Single Mucosal, but Not Parenteral, Immunization with Recombinant Adenoviral-Based Vaccine Provides Potent Protection from Pulmonary Tuberculosis. Journal of Immunology. 173:6357-6365. 2004
- Use of cytokines in infection. Expert Opinion on Emerging Drugs. 9:223-236. 2004
- Activation of CD8 T Cells by Mycobacterial Vaccination Protects against Pulmonary Tuberculosis in the Absence of CD4 T Cells. Journal of Immunology. 173:4590-4597. 2004
- Differential Regulation of DAP12 and Molecules Associated with DAP12 during Host Responses to Mycobacterial Infection. Infection and Immunity. 72:2477-2483. 2004
- Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-κB-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli. Journal of Immunology. 172:4535-4544. 2004
- TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. Journal of Clinical Investigation. 113:401-413. 2004
- TNF-α is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. Journal of Clinical Investigation. 113:401-413. 2004
- Protection from endotoxemia by adenoviral-mediated gene transfer of human bactericidal/permeability-increasing protein. Blood. 103:93-99. 2004
- Single Intranasal MucosalMycobacterium bovisBCG Vaccination Confers Improved Protection Compared to Subcutaneous Vaccination against Pulmonary Tuberculosis. Infection and Immunity. 72:238-246. 2004
- Transplantation of Monocytes: A Novel Strategy forIn VivoAugmentation of Collateral Vessel Growth. Human gene therapy. Clinical development. 15:1-12. 2004
- Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis. Journal of Immunology. 171:5470-5481. 2003
- Pulmonary 18Fluorodeoxyglucose uptake in infants of very low birth weight with and without intrauterine inflammation. Journal of Pediatrics. 143:470-476. 2003
- Modulation of Hepatic Granulomatous Responses by Transgene Expression of DAP12 or TREM-1-Ig Molecules. American Journal of Pathology. 162:1191-1201. 2003
- Cytokines - Preface. Current Pharmaceutical Design. 9. 2003
- Role of DAP12 in Innate and Adaptive Immune Responses. Current Pharmaceutical Design. 9:7-10. 2003
- GM-CSF Transgene-Based Adjuvant Allows the Establishment of Protective Mucosal Immunity Following Vaccination with Inactivated Chlamydia trachomatis. Journal of Immunology. 169:6324-6331. 2002
- Tuberculosis vaccines: the past, present and future. Expert Review of Vaccines. 1:341-354. 2002
- Endogenous Granulocyte-Macrophage Colony-Stimulating Factor Overexpression In Vivo Results in the Long-Term Recruitment of a Distinct Dendritic Cell Population with Enhanced Immunostimulatory Function. Journal of Immunology. 169:2875-2885. 2002
- Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor. Cancer Gene Therapy. 9:778-786. 2002
- Enhanced immunogenicity of BCG vaccine by using a viral-based GM-CSF transgene adjuvant formulation. Vaccine. 20:2887-2898. 2002
- Adenoviral-Mediated Gene Transfer of Lymphotactin to the Lungs of Mice and Rats Results in Infiltration and Direct Accumulation of CD4+, CD8+, and NK Cells. Journal of Interferon and Cytokine Research. 22:573-582. 2002
- Transplant immunosuppression enhances efficiency of adenoviral-mediated gene retransfection: inhibition of interferon-γ and immunoglobin G. Annals of Thoracic Surgery. 73:1092-1097. 2002
- Reduced tissue macrophage population in the lung by anticancer agent cyclophosphamide: restoration by local granulocyte macrophage–colony-stimulating factor gene transfer. Blood. 99:1246-1252. 2002
- Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation. Clinical and Experimental Immunology. 113:157-165. 2001
- Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw. Clinical and Experimental Immunology. 120:375-383. 2001
- Cytokines - Preface. Current Pharmaceutical Design. 7:U2-U2. 2001
- Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene. Journal of Immunology. 167:375-383. 2001
- The Hunt for New Tuberculosis Vaccines: Anti-TB Immunity and Rational Design of Vaccines. Current Pharmaceutical Design. 7:1015-1037. 2001
- Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required for host defense against viral infections. Cellular and Molecular Biology. 47:689-694. 2001
- Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required.. Cellular and Molecular Biology. 47:689-694. 2001
- Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin. American Journal of Respiratory and Critical Care Medicine. 163:770-777. 2001
- Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. American Journal of Respiratory and Critical Care Medicine. 163:770-777. 2001
- Genetically Determined Disparate Innate and Adaptive Cell-Mediated Immune Responses to PulmonaryMycobacterium bovisBCG Infection in C57BL/6 and BALB/c Mice. Infection and Immunity. 68:6946-6953. 2000
- Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction. Journal of Leukocyte Biology. 68:897-902. 2000
- Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin‐10 on organ allograft and tumour rejection. Immunology. 101:233-241. 2000
- Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4–Deficient Mice. American Journal of Respiratory Cell and Molecular Biology. 23:327-334. 2000
- IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proceedings of the National Academy of Sciences of the United States of America. 97:6007-6012. 2000
- Consideration of Cytokines as Therapeutics Agents or Targets. Current Pharmaceutical Design. 6:599-611. 2000
- Cytokines - Preface. Current Pharmaceutical Design. 6:U2-U2. 2000
- Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung. Blood. 95:2337-2345. 2000
- IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes. Journal of Immunology. 164:2575-2584. 2000
- Interleukin 10 gene transfer prevents experimental colitis in rats. Gut. 46:344-349. 2000
- Current understanding of macrophage type 1 cytokine responses during intracellular infections.. Histology and Histopathology. 15:199-205. 2000
- Transient Transgenic Approaches for Investigating the Role of Granulocyte- Macrophage Colony-Stimulating Factor in Pulmonary Inflammatory and Immune Diseases. Methods in Molecular Medicine. 44:161-178. 2000
- Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice. American Journal of Respiratory Cell and Molecular Biology. 21:586-596. 1999
- Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway. American Journal of Respiratory Cell and Molecular Biology. 21:317-326. 1999
- Replication-Defective Adenovirus Infection ReducesHelicobacter felisColonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner. Infection and Immunity. 67:4539-4544. 1999
- Adenoviral-Mediated Gene Transfer of Interleukin-6 in Rat Lung Enhances Antiviral Immunoglobulin A and G Responses in Distinct Tissue Compartments. Biochemical and Biophysical Research Communications. 258:332-335. 1999
- Macrophages are a significant source of type 1 cytokines during mycobacterial infection. Journal of Clinical Investigation. 103:1023-1029. 1999
- Cytokines and pulmonary inflammatory and immune diseases.. Histology and Histopathology. 14:185-201. 1999
- Adenoviral infection inhibits allergic airways inflammation in mice. Clinical and Experimental Allergy. 28:1581-1590. 1998
- GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.. Journal of Clinical Investigation. 102:1704-1714. 1998
- Protection by CD4 or CD8 T Cells against PulmonaryMycobacterium bovisBacillus Calmette-Guérin Infection. Infection and Immunity. 66:5537-5542. 1998
- Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.. Journal of Clinical Investigation. 102:1132-1141. 1998
- Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts. American Journal of Pathology. 153:825-832. 1998
- Lack of Both Types 1 and 2 Cytokines, Tissue Inflammatory Responses, and Immune Protection During Pulmonary Infection byMycobacterium bovisBacille Calmette-Guérin in IL-12-Deficient Mice. Journal of Immunology. 160:6101-6111. 1998
- Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.. Journal of Clinical Investigation. 101:1342-1353. 1998
- Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans. Human gene therapy. Clinical development. 9:541-551. 1998
- Adenovirus-mediated expression of an elastase-specific inhibitor (elafin): a comparison of different promoters. Gene Therapy. 5:352-360. 1998
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.. Journal of Clinical Investigation. 101:311-320. 1998
- Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis.. Laboratory Investigation. 77:615-622. 1997
- Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions. Pneumologie. 51:396. 1997
- Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.. Journal of Clinical Investigation. 100:768-776. 1997
- Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung.. Chest. 111:137S. 1997
- In vivo adenovirus-mediated expression of human pre-elafin, a potent neutrophil elastase inhibitor.. Chest. 111:128S-129S. 1997
- Transient Gene Transfer and Expression in the Lung. Chest. 111:89S-94S. 1997
- Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.. American Journal of Respiratory Cell and Molecular Biology. 16:510-520. 1997
- Adenoviral vector-mediated interleukin-10 expression in vivo: intramuscular gene transfer inhibits cytokine responses in endotoxemia. Gene Therapy. 4:140-149. 1997
- Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.. American Journal of Pathology. 150:59-66. 1997
- Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung.. Journal of Immunology. 157:5076-5084. 1996
- Adenoviral gene transfer of macrophage inflammatory protein-2 in rat lung.. American Journal of Pathology. 149:1395-1403. 1996
- CD40 expression by human peripheral blood eosinophils.. Journal of Clinical Investigation. 97:1761-1766. 1996
- Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation. Journal of Leukocyte Biology. 59:481-488. 1996
- Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.. Journal of Clinical Investigation. 97:1102-1110. 1996
- Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo.. American Journal of Respiratory Cell and Molecular Biology. 12:232-237. 1995
- Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.. Journal of Immunology. 153:4059-4069. 1994
- Tissue directed recruitment of mononuclear cells to the lung using a recombinant adenovirus expressing murine RANTES. Cytokine. 6:544-544. 1994
- Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils.. Journal of Experimental Medicine (JEM). 180:711-715. 1994
- A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. European Journal of Immunology. 24:1463-1466. 1994
- CYTOKINE EXPRESSION BY NEUTROPHILS AND MACROPHAGES IN-VIVO - ENDOTOXIN INDUCES TUMOR-NECROSIS-FACTOR-ALPHA, MACROPHAGE INFLAMMATORY PROTEIN-2, INTERLEUKIN-1-BETA, AND INTERLEUKIN-6 BUT NOT RANTES OR TRANSFORMING GROWTH FACTOR-BETA(1) MESSENGER-RNA EXPRESSION IN ACUTE LUNG INFLAMMATION (VOL 10, PG 148, 1994). American Journal of Respiratory Cell and Molecular Biology. 10:U5-U5. 1994
- Cytokine expression by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha, macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not RANTES or transforming growth factor-beta 1 mRNA expression in acute lung inflammation.. American Journal of Respiratory Cell and Molecular Biology. 10:148-153. 1994
- Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue.. American Journal of Pathology. 143:1009-1015. 1993
- Lipopolysaccharide Induces Expression of Granulocyte/Macrophage Colony-stimulating Factor, Interleukin-8, and Interleukin-6 in Human Nasal, but Not Lung, Fibroblasts: Evidence for Heterogeneity within the Respiratory Tract. American Journal of Respiratory Cell and Molecular Biology. 9:255-263. 1993
- Cytokines in lung and airways fibrosis.. Regional immunology. 5:201-206. 1993
- IL-1 beta and IL-6 gene expression in alveolar macrophages: modulation by extracellular matrices. American Journal of Physiology. 262:L600-L605. 1992
- Human Upper Airway Structural Cell-derived Cytokines Support Human Peripheral Blood Monocyte Survival: A Potential Mechanism for Monocyte/Macrophage Accumulation in the Tissue. American Journal of Respiratory Cell and Molecular Biology. 6:212-218. 1992
- Interaction of nonactivated alveolar macrophages with Thermoactinomyces vulgaris in vitro.. National Medical Journal of China. 100:977-982. 1987
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preprints
- Safety and immunopotency of an adenovirus-vectored tuberculosis vaccine delivered via inhaled aerosol to healthy humans: a dose and route comparison phase 1b study 2021
- Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 2021