Journal article
PagP Crystallized from SDS/Cosolvent Reveals the Route for Phospholipid Access to the Hydrocarbon Ruler
Abstract
Enzymatic reactions involving bilayer lipids occur in an environment with strict physical and topological constraints. The integral membrane enzyme PagP transfers a palmitoyl group from a phospholipid to lipid A in order to assist Escherichia coli in evading host immune defenses during infection. PagP measures the palmitoyl group with an internal hydrocarbon ruler that is formed in the interior of the eight-stranded antiparallel β barrel. The …
Authors
Cuesta-Seijo JA; Neale C; Khan MA; Moktar J; Tran CD; Bishop RE; Pomès R; Privé GG
Journal
Structure, Vol. 18, No. 9, pp. 1210–1219
Publisher
Elsevier
Publication Date
September 2010
DOI
10.1016/j.str.2010.06.014
ISSN
0969-2126