Lung Cancer in Humans Is Not Associated with Lifetime Total Alcohol Consumption or with Genetic Variation in Alcohol Dehydrogenase 3 (ADH3) Conference Paper uri icon

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abstract

  • Although there is clear evidence that smoking is the primary risk factor for lung cancer, not all variation in disease risk is understood. There is some evidence that alcohol may contribute to risk. We examined lifetime and recent (12-24 mo previous) alcohol consumption in relation to risk of lung cancer in a case-control study in western New York. In addition we examined the alcohol dehydrogenase 3 (ADH3) genotype in relation to lung cancer risk; ADH3 is rate limiting in alcohol metabolism and has a functional polymorphism. We interviewed incident, primary, histologically confirmed lung cancer cases (n = 111) in two counties. Controls were randomly selected from among those residing in the counties, frequency-matched to cases for age and race (n = 1546). Lifetime and recent total alcohol and beverage-specific alcohol consumption as well as relevant confounders were assessed by interview. ADH3 genotype was evaluated by a PCR-restriction fragment length polymorphism assay. Because of the small sample size, power was limited and CI were wide. Residual confounding by smoking remains a concern. Although we found a significant trend for increased risk for beer consumption in the recent period (odds ratio 1.67, 95% CI 0.96-2.92, P for trend = 0.05), chance cannot be ruled out as an explanation. We found no evidence of risk related to lifetime alcohol consumption nor evidence that alcohol dehydrogenase genotype modifies risk related to alcohol and lung cancer.

authors

  • Freudenheim, Jo L
  • Ram, Malathi
  • Nie, Jing
  • Muti, Paola
  • Trevisan, Maurizio
  • Shields, Peter G
  • Bandera, Elisa V
  • Campbell, Lucy A
  • McCann, Susan E
  • Schunemann, Holger
  • Carosella, Anne Marie
  • Vito, Dominica
  • Russell, Marcia
  • Nochajski, Thomas H
  • Goldman, Radoslav

publication date

  • November 1, 2003