selected scholarly activity
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conferences
- The Effect of Benzodiazepine-free Cardiac Anesthesia on the Frequency of Positive Delirium Assessments after Cardiac Surgery: A Secondary Analysis of the B-Free Pragmatic Cluster Randomized Crossover Trial. Anesthesia and Analgesia. 432-433. 2024
- SYNERGY—Everolimus-Eluting Stent With a Bioabsorbable Polymer in ST-Elevation Myocardial Infarction: CLEAR SYNERGY OASIS-9 Registry. American Journal of Cardiology. 111-117. 2024
- CLINICAL PHENOGROUPS ARE MORE EFFECTIVE THAN LEFT VENTRICULAR EJECTION FRACTION CATEGORIES IN STRATIFYING HEART FAILURE OUTCOMES. Journal of the American College of Cardiology. 587-587. 2021
- FACTORS ASSOCIATED WITH UNDER-ENROLMENT OF FEMALES IN CLINICAL TRIALS OF HEART FAILURE WITH REDUCED EJECTION FRACTION: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal of the American College of Cardiology. 1059-1059. 2020
- Effect of Patient-Centered Transitional Care Services in Patients Hospitalized for Heart Failure: Clinical and Sex Specific Outcomes of the PACT-HF Randomized Clinical Trial. Circulation. E1001-E1001. 2019
- Clinical Characteristics of Patients With Heart Failure Show a Continuum Across the Spectrum of Left Ventricular Ejection Fraction: A Substudy of the Patient-Centered Care Transitions in Heart Failure Randomized Clinical Trial. Circulation. 2019
- Small-Volume Tubes to Reduce Anemia and Transfusion (STRATUS): A Pragmatic Stepped Wedge Cluster Randomized Trial. Blood. 3685-3685. 2019
- A point-of-care risk score predicts 30-day readmission in patients hospitalized with heart failure (HF): derivation and validation of the LENT index. European Heart Journal. 3953-3953. 2019
- 254-OR: Novel Biomarkers Predicting Renal Dysfunction in People with Dysglycemia in the ORIGIN Trial. Diabetes. 2019
- TESTOSTERONE AND SEX HORMONE-BINDING GLOBULIN IN DYSGLYCEMIC WOMEN AT HIGH CARDIOVASCULAR RISK: A REPORT FROM THE OUTCOME REDUCTION WITH AN INITIAL GLARGINE INTERVENTION TRIAL. Journal of the American College of Cardiology. 1760-1760. 2019
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journal articles
- Comparative performance of risk prediction indices for mortality or readmission following heart failure hospitalization.. ESC heart failure. 12:1227-1236. 2025
- Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial.. JAMA Surgery. 160:286-294. 2025
- Colchicine in Acute Myocardial Infarction.. New England Journal of Medicine. 392:633-642. 2025
- Routine Spironolactone in Acute Myocardial Infarction.. New England Journal of Medicine. 392:643-652. 2025
- Statistical Methods for Analyzing EQ-5D in Randomized Clinical Trials: A Systematic Literature Review.. Value in Health. S1098-3015(25)00067-1. 2025
- Long-term clinical outcomes and healthcare resource utilization in male and female patients following hospitalization for heart failure.. European Journal of Heart Failure. 27:377-387. 2025
- Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials.. European Heart Journal. 45:4902-4916. 2024
- Do nonglycaemic effects such as weight loss account for HbA1c lowering with efpeglenatide?: Insights from the AMPLITUDE-O trial.. Diabetes, Obesity and Metabolism. 26:6080-6084. 2024
- Secondary Conduits in Coronary Artery Bypass Grafting Surgery.. Annals of Thoracic Surgery. 118:1245-1253. 2024
- Risk of Stroke or Systemic Embolism According to Baseline Frequency and Duration of Subclinical Atrial Fibrillation: Insights From the ARTESiA Trial.. Circulation. 150:1747-1755. 2024
- Sex-specific clinical outcomes and healthcare resource utilization in the 5 years following hospitalization for heart failure. European Heart Journal. 45. 2024
- Improving analysis of cognitive outcomes in cardiovascular trials using different statistical approaches.. Trials. 25:644. 2024
- Design and rationale of the CLEAR SYNERGY (OASIS 9) trial: A 2x2 factorial randomized controlled trial of colchicine versus placebo and spironolactone vs placebo in patients with myocardial infarction. American Heart Journal. 275:173-182. 2024
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Determinants of serious health
outcome‐free status inmiddle‐aged and older people with dysglycaemia: Exploratory analysis of theORIGIN trial. Diabetes, Obesity and Metabolism. 26:3272-3280. 2024 - Effect of a transitional care model following hospitalization for heart failure: 3‐year outcomes of the Patient‐Centered Care Transitions in Heart Failure (PACT‐HF) randomized controlled trial. European Journal of Heart Failure. 26:652-660. 2024
- Visit-to-visit variability in multiple biological measurements and cognitive performance and risk of cardiovascular disease: A cohort study. Cerebral Circulation - Cognition and Behavior. 6:100223-100223. 2024
- Cognitive performance following stroke, transient ischaemic attack, myocardial infarction, and hospitalisation: an individual participant data meta-analysis of six randomised controlled trials. The Lancet Healthy Longevity. 4:e665-e674. 2023
- Sex hormone-binding globulin and heart failure hospitalizations in patients with dysglycemia. Diabetes Research and Clinical Practice. 206:111010-111010. 2023
- Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care. Journal of the American Medical Association (JAMA). 330:1872-1872. 2023
- Sex hormone-binding globulin and heart failure hospitalizations in patients with dysglycemia - Experiences from the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial. European Heart Journal. 44:ehad655.926. 2023
- Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial. The Lancet. 402:1627-1635. 2023
- Small-volume tubes to reduce anemia and transfusion (STRATUS): a pilot study. Canadian Journal of Anaesthesia. 70:1797-1806. 2023
- Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium (B-Free): A Protocol for a Multi-centre Randomized Cluster Crossover Trial. CJC OPEN. 5:691-699. 2023
- Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis. Diabetes Care. 46:1046-1051. 2023
- Conduit selection and early graft failure in coronary artery bypass surgery: A post hoc analysis of the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) coronary artery bypass grafting study. Journal of Thoracic and Cardiovascular Surgery. 165:1080-1089.e1. 2023
- World-wide variations in tests of cognition and activities of daily living in participants of six international randomized controlled trials. Cerebral Circulation - Cognition and Behavior. 5:100176-100176. 2023
- Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial . EuroIntervention. 18:e888-e896. 2022
- Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations. ACP journal club. 175:1658-1665. 2022
- Impact of Bioelectrical Impedance–Guided Fluid Management and Vitamin D Supplementation on Left Ventricular Mass in Patients Receiving Peritoneal Dialysis: A Randomized Controlled Trial. American Journal of Kidney Diseases. 79:820-831. 2022
- Biomarkers of Prevalent and Incident Cognitive Dysfunction in People with Dysglycemia: Data from the ORIGIN Trial. Journal of Alzheimer's Disease. 87:1143-1150. 2022
- High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality. New England Journal of Medicine. 386:827-836. 2022
- Sex-Specific Clinical Outcomes of the PACT-HF Randomized Trial. Circulation. Heart Failure. 14:e008548. 2021
- Standardized Assessment of Global activities in the Elderly scale in adult cardiac surgery patients. British Journal of Anaesthesia. 127:539-546. 2021
- Skeletonized vs Pedicled Internal Mammary Artery Graft Harvesting in Coronary Artery Bypass Surgery. JAMA cardiology. 6:1042-1042. 2021
- Clinical phenogroups are more effective than left ventricular ejection fraction categories in stratifying heart failure outcomes. ESC heart failure. 8:2741-2754. 2021
- Derivation and validation of a two‐variable index to predict 30‐day outcomes following heart failure hospitalization. ESC heart failure. 8:2690-2697. 2021
- NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia – A brief report from the ORIGIN trial. Journal of Diabetes and its Complications. 35:107928-107928. 2021
- Patient reported outcome measures in clinical trials should be initially analyzed as continuous outcomes for statistical significance and responder analyses should be reserved as secondary analyses. Journal of Clinical Epidemiology. 134:95-102. 2021
- Testosterone and sex hormone-binding globulin in dysglycemic women at high cardiovascular risk: A report from the Outcome Reduction with an Initial Glargine Intervention trial. Diabetes and Vascular Disease Research. 18:147916412110024-147916412110024. 2021
- The LENT index predicts 30 day outcomes following hospitalization for heart failure. ESC heart failure. 8:518-526. 2021
- Variations in incidence of venous thromboembolism in low-, middle-, and high-income countries. Cardiovascular Research (CVR). 117:576-584. 2021
- Designing, Conducting, Monitoring, and Analyzing Data from Pragmatic Randomized Clinical Trials: Proceedings from a Multi-stakeholder Think Tank Meeting. Therapeutic Innovation and Regulatory Science. 54:1477-1488. 2020
- Selecting the Optimal Level of Clustering: An Approach to Trial Design Decision Making. Journal of the American College of Surgeons. 231:397-400. 2020
- Restricted versus liberal intraoperative benzodiazepine use in cardiac anaesthesia for reducing delirium (B-Free Pilot): a pilot, multicentre, randomised, cluster crossover trial. British Journal of Anaesthesia. 125:38-46. 2020
- Characteristics and outcomes of atrial fibrillation in patients without traditional risk factors: an RE-LY AF registry analysis. Europace. 22:870-877. 2020
- Novel Biomarkers for Change in Renal Function in People With Dysglycemia. Diabetes Care. 43:433-439. 2020
- Variations in stepped-wedge cluster randomized trial design: Insights from the Patient-Centered Care Transitions in Heart Failure trial. American Heart Journal. 220:116-126. 2020
- The DIalysis Symptom COntrol-Restless Legs Syndrome (DISCO-RLS) Trial: A Protocol for a Randomized, Crossover, Placebo-Controlled Blinded Trial. Canadian Journal of Kidney Health and Disease. 7:205435812096895-205435812096895. 2020
- Correction to: Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial. Trials. 20:595. 2019
- P6351A point-of-care risk score predicts 30-day readmission in patients hospitalized with heart failure (HF): derivation and validation of the LENT index. European Heart Journal. 40:ehz746.0947. 2019
- Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. The Lancet. 394:1022-1029. 2019
- Electronic Versus Traditional Data Collection: A Multicenter Randomized Controlled Perioperative Pain Trial. Canadian Journal of Pain. 3:16-25. 2019
- Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial. European Journal of Preventive Cardiology (EJPC). 26:847-854. 2019
- Effects of blood pressure and lipid lowering on cognition. Neurology. 92:e1435-e1446. 2019
- Effect of Patient-Centered Transitional Care Services on Clinical Outcomes in Patients Hospitalized for Heart Failure. Journal of the American Medical Association (JAMA). 321:753-753. 2019
- The association of basal insulin treatment versus standard care with outcomes in anti‐GAD positive and negative subjects: A post‐hoc analysis of the ORIGIN trial. Diabetes, Obesity and Metabolism. 21:429-433. 2019
- When and how should we cluster and cross over: methodological and ethical issues (letter 2). Canadian Journal of Anaesthesia. 66:237-238. 2019
- Rivaroxaban, Aspirin, or Both to Prevent Early Coronary Bypass Graft Occlusion. Journal of the American College of Cardiology. 73:121-130. 2019
- Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial. Trials. 19:688. 2018
- 4940Predicting risk at the point of care: NT-proBNP improves performance of the LACE index among patients hospitalized for Heart Failure (HF). European Heart Journal. 39:ehy566.4940. 2018
- P6544All you need is LE: utility of an abbreviated LACE score in predicting 30-day outcomes among patients hospitalized for Heart Failure (HF). European Heart Journal. 39:ehy566.p6544. 2018
- P836Benzodiazepine-free cardiac anesthesia for reduction of delirium (B-Free): a two-centre pilot study to determine the feasibility of a multi-centre, randomized, cluster crossover trial. European Heart Journal. 39:ehy564.p836. 2018
- The role of randomized cluster crossover trials for comparative effectiveness testing in anesthesia: design of the Benzodiazepine-Free Cardiac Anesthesia for Reduction in Postoperative Delirium (B-Free) trial. Canadian Journal of Anaesthesia. 65:813-821. 2018
- Knowledge to action: Rationale and design of the Patient-Centered Care Transitions in Heart Failure (PACT-HF) stepped wedge cluster randomized trial. American Heart Journal. 199:75-82. 2018
- Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world. Heart. 104:581-587. 2018
- Power of the adjusted Q statistic to evaluate heterogeneity in meta-analyses of cluster randomized trials. Communications in Statistics Part B: Simulation and Computation. 46:7062-7073. 2017
- The effect of basal insulin glargine on the fibrinolytic system and von Willebrand factor in people with dysglycaemia and high risk for cardiovascular events: Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial. Diabetes and Vascular Disease Research. 14:345-352. 2017
- Validation of the ORIGIN Cardiovascular Biomarker Panel and the Value of Adding Troponin I in Dysglycemic People. Journal of Clinical Endocrinology and Metabolism (JCEM). 102:2251-2257. 2017
- Growth Differentiation Factor 15 as a Novel Biomarker for Metformin. Diabetes Care. 40:280-283. 2017
- Utility of the LACE index at the bedside in predicting 30-day readmission or death in patients hospitalized with heart failure. American Heart Journal. 179:51-58. 2016
- Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE). Diabetes Care. 39:709-716. 2016
- Identifying Novel Biomarkers for Cardiovascular Events or Death in People With Dysglycemia. Circulation. 132:2297-2304. 2015
- Randomized Controlled Trial of Radiation Protection With a Patient Lead Shield and a Novel, Nonlead Surgical Cap for Operators Performing Coronary Angiography or Intervention. Circulation: Cardiovascular Interventions. 8:e002384. 2015
- Risk Prediction for Early CKD in Type 2 Diabetes. American Society of Nephrology. Clinical Journal. 10:1371-1379. 2015
- Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events. New England Journal of Medicine. 371:612-623. 2014
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preprints