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Routine Spironolactone in Acute Myocardial...
Journal article

Routine Spironolactone in Acute Myocardial Infarction

Abstract

BACKGROUND: Mineralocorticoid receptor antagonists have been shown to reduce mortality in patients after myocardial infarction with congestive heart failure. Whether routine use of spironolactone is beneficial after myocardial infarction is uncertain. METHODS: In this multicenter trial with a 2-by-2 factorial design, we randomly assigned patients with myocardial infarction who had undergone percutaneous coronary intervention to receive either …

Authors

Jolly SS; d’Entremont M-A; Pitt B; Lee SF; Mian R; Tyrwhitt J; Kedev S; Montalescot G; Cornel JH; Stanković G

Journal

The New England Journal of Medicine, Vol. 392, No. 7, pp. 643–652

Publisher

Massachusetts Medical Society

Publication Date

February 13, 2025

DOI

10.1056/nejmoa2405923

ISSN

0028-4793