Journal article
Effects of blood pressure and lipid lowering on cognition: Results from the HOPE-3 study
Abstract
OBJECTIVE: To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk.
METHODS: The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 × 2 factorial design. Participants without known cardiovascular disease or need for treatment were …
Authors
Bosch J; O'Donnell M; Swaminathan B; Lonn EM; Sharma M; Dagenais G; Diaz R; Khunti K; Lewis BS; Avezum A
Journal
Neurology, Vol. 92, No. 13, pp. e1435–e1446
Publisher
Wolters Kluwer
Publication Date
March 26, 2019
DOI
10.1212/wnl.0000000000007174
ISSN
0028-3878