Journal article
Basal insulin glargine and microvascular outcomes in dysglycaemic individuals: results of the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial
Abstract
Aims/hypothesisAs glycaemia and the incidence of microvascular diabetes complications follow a log-linear relationship, it becomes increasingly difficult to demonstrate a microvascular benefit of glucose-lowering when the HbA1c level is close to normal.MethodsThe Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial randomised 12,537 people with diabetes, impaired glucose tolerance or impaired fasting glucose to receive …
Authors
The ORIGIN trial investigators; Gilbert RE; Mann JFE; Hanefeld M; Spinas G; Bosch J; Yusuf S; Gerstein HC
Journal
Diabetologia, Vol. 57, No. 7, pp. 1325–1331
Publisher
Springer Nature
Publication Date
July 2014
DOI
10.1007/s00125-014-3238-4
ISSN
0012-186X