Journal article
Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells Modulation of cellular signals regulating cell cycle and survival
Abstract
PURPOSE: To analyze the (i) expression of AMPK in a variety of epithelial cancer cells, (ii) regulation of AMPK subunit expression by ionizing radiation (IR) and (iii) impact of AMPK on signaling pathways regulating cell cycle and survival.
METHODS AND MATERIALS: Human lung, prostate, and breast normal and cancer cells were treated with 0 or 8 Gy IR and mRNA and protein levels of AMPK were evaluated by RT-PCR and immunoblotting 24 or 48 h …
Authors
Sanli T; Storozhuk Y; Linher-Melville K; Bristow RG; Laderout K; Viollet B; Wright J; Singh G; Tsakiridis T
Journal
Radiotherapy and Oncology, Vol. 102, No. 3, pp. 459–465
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.radonc.2011.11.014
ISSN
0167-8140