Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli

Bacteria generally possess multiple σ factors that, based on structural and functional similarity, divide into two families: σ(70) and σ(N) . Many studies have revealed σ factor competition within the σ(70) family, while the competition between σ(N) and σ(70) families has yet to be fully explored. Here we report a global antagonistic effect on gene expression between two alternative σ factors, σ(N) (RpoN) and a σ(70) family protein σ(S) (RpoS). …