Journal article
Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia
Abstract
The type I interferons (IFNs) normally suppress tumor growth by phosphorylating and activating the signal transducer and activator of transcription 1 (STAT1), but also briefly activate STAT3, which promotes cell growth. In chronic lymphocytic leukemia (CLL) cells, the duration of IFN-mediated STAT3 phosphorylation was found to exhibit significant interpatient variability and was prolonged in cells with high risk features, such as 11q- and …
Authors
Tomic J; Lichty B; Spaner DE
Journal
Blood, Vol. 117, No. 9, pp. 2668–2680
Publisher
American Society of Hematology
Publication Date
March 3, 2011
DOI
10.1182/blood-2010-05-285999
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell ProliferationDNA-Binding ProteinsFemaleHumansInterferonsLeukemia, Lymphocytic, Chronic, B-CellLymphoma, B-CellMaleMiddle AgedPhorbol EstersPhosphorylationProtein Serine-Threonine KinasesReactive Oxygen SpeciesReference StandardsSTAT3 Transcription FactorSignal TransductionTYK2 KinaseTumor Suppressor Protein p53Tumor Suppressor Proteins