Journal article
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
Abstract
Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to treat urea cycle disorders under the trade name Buphenyl. Recent studies however have explored 4-PBA in the context of a low weight molecular weight chemical chaperone. Its properties as a chemical chaperone prevent misfolded protein aggregation and alleviate …
Authors
Kolb PS; Ayaub EA; Zhou W; Yum V; Dickhout JG; Ask K
Journal
The International Journal of Biochemistry & Cell Biology, Vol. 61, , pp. 45–52
Publisher
Elsevier
Publication Date
April 2015
DOI
10.1016/j.biocel.2015.01.015
ISSN
1357-2725