Journal article
IQGAP2, A candidate tumour suppressor of prostate tumorigenesis
Abstract
Loss of IQGAP2 contributes to the tumorigenesis of hepatocellular carcinoma and gastric cancer. However, whether IQGAP2 also suppresses prostate tumorigenesis remains unclear. We report here that IQGAP2 is a candidate tumour suppressor of prostate cancer (PC). Elevated IQGAP2 was detected in prostatic intraepithelial neoplasia (PIN), early stages of PCs (Gleason score ≤3), and androgen-dependent LNCaP PC cells. However, IQGAP2 was expressed at …
Authors
Xie Y; Yan J; Cutz J-C; Rybak AP; He L; Wei F; Kapoor A; Schmidt VA; Tao L; Tang D
Journal
Biochimica et Biophysica Acta, Vol. 1822, No. 6, pp. 875–884
Publisher
Elsevier
Publication Date
June 2012
DOI
10.1016/j.bbadis.2012.02.019
ISSN
0006-3002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCadherinsCell Line, TumorCell Transformation, NeoplasticGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansMaleMiceMice, Inbred NODMice, SCIDProstateProstatic Intraepithelial NeoplasiaProstatic NeoplasmsProto-Oncogene Proteins c-aktRNA InterferenceRNA, Small InterferingTransplantation, HeterologousTumor Suppressor Proteinsras GTPase-Activating Proteins