Journal article
Effect of Leptin on Vascular Calcification in Apolipoprotein E–Deficient Mice
Abstract
OBJECTIVE: The adipocytokine leptin has been proposed to increase cardiovascular risk in both obese and diabetic individuals. In the current study, therefore, we used apoE-deficient mice to examine the effects of leptin on both lesion size and calcification.
METHODS AND RESULTS: Mice were treated with once daily intraperitoneal injections of leptin (125 microg/mouse/d) for 2 months. The mice were then euthanized, and sections of the aortic root …
Authors
Zeadin M; Butcher M; Werstuck G; Khan M; Yee CK; Shaughnessy SG
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 29, No. 12, pp. 2069–2075
Publisher
Wolters Kluwer
Publication Date
December 2009
DOI
10.1161/atvbaha.109.195255
ISSN
1079-5642