Journal article
Adenoviral Transfer of the Murine Oncostatin M Gene Suppresses Dextran-Sodium Sulfate-Induced Colitis
Abstract
The use of biologics has promising potential in the treatment of inflammation. Studies with cultured cells and mouse models of disease have ascribed proinflammatory and anti-inflammatory functions to oncostatin M (OSM) and the related cytokine, interleukin-6 (IL-6). Here, we examined the effect of systemic administration of adenoviral (Ad) vectors encoding either murine OSM (AdMuOSM) or murine IL-6 (AdMuIL-6) in a mouse model of colitis. BALB/c …
Authors
Sanchez AL; Langdon CM; Akhtar M; Lu J; Richards CD; Bercik P; McKay DM
Journal
Journal of Interferon & Cytokine Research, Vol. 23, No. 4, pp. 193–201
Publisher
Mary Ann Liebert
Publication Date
April 2003
DOI
10.1089/107999003765027393
ISSN
1079-9907