Journal article
Autoimmune Manifestations in the 3xTg-AD Model of Alzheimer's Disease
Abstract
BACKGROUND: Immune system activation is frequently reported in patients with Alzheimer's disease (AD). However, it remains unknown whether this is a cause, a consequence, or an epiphenomenon of brain degeneration.
OBJECTIVE: The present study examines whether immunological abnormalities occur in a well-established murine AD model and if so, how they relate temporally to behavioral deficits and neuropathology.
Authors
Marchese M; Cowan D; Head E; Ma D; Karimi K; Ashthorpe V; Kapadia M; Zhao H; Davis P; Sakic B
Journal
Journal of Alzheimer’s Disease, Vol. 39, No. 1, pp. 191–210
Publisher
SAGE Publications
Publication Date
2014
DOI
10.3233/jad-131490
ISSN
1387-2877