PSA affects prostate cancer cell invasion in vitro and induces an osteoblastic phenotype in bone in vivo

Background:Patients with advanced prostate cancer frequently have a poor prognosis as a result of metastasis and present with high serum PSA levels. There is evidence suggesting that the serine protease activity of PSA could be involved in the invasion and metastasis of prostate cancer. In this study, we determined the effects of PSA and its precursor, pro-PSA, on invasion and the type of bone metastasis.Methods:We stably transfected prostate …