Journal article
PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells
Abstract
Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in mesangial cells through transactivation of the EGF receptor (EGFR). In addition, in renal tubular cells, glucose-induced secretion of TGF-beta requires phosphoinositide-3-OH kinase, suggesting a possible role for Akt in the modulation of TGF-beta expression, but the mechanisms of Akt …
Authors
Wu D; Peng F; Zhang B; Ingram AJ; Kelly DJ; Gilbert RE; Gao B; Krepinsky JC
Journal
Journal of the American Society of Nephrology, Vol. 20, No. 3, pp. 554–566
Publisher
Wolters Kluwer
Publication Date
March 2009
DOI
10.1681/asn.2008040445
ISSN
1046-6673
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NephropathiesEnzyme ActivationErbB ReceptorsFemaleGlucoseIndolesKidneyMaleimidesMesangial CellsModels, BiologicalPhosphatidylinositol 3-KinasesPhosphorylationProtein Kinase CProtein Kinase C betaProtein Kinase InhibitorsProto-Oncogene Proteins c-aktRatsRecombinant ProteinsSignal TransductionTranscription Factor AP-1Transcriptional ActivationTransforming Growth Factor beta1Up-Regulation