Journal article
Polyurethane modified with an antithrombin‐heparin complex via polyethylene oxide linker/spacers: Influence of PEO molecular weight and PEO‐ATH bond on catalytic and direct anticoagulant functions
Abstract
A segmented polyurethane (PU) was modified with polyethylene oxides (PEO) of varying molecular weight and end group. The PEO served as linker/spacers to immobilize an antithrombin-heparin (ATH) anticoagulant complex on the PU. Isocyanate groups were introduced into the PU to enable attachment of either "conventional" homo-bifunctional dihydroxy-PEO (PEO-OH surface) or a hetero-bifunctional amino-carboxy-PEO (PEO-COOH surface). The PEO surfaces …
Authors
Sask KN; Berry LR; Chan AKC; Brash JL
Journal
Journal of Biomedical Materials Research Part A, Vol. 100A, No. 10, pp. 2821–2828
Publisher
Wiley
Publication Date
October 2012
DOI
10.1002/jbm.a.34218
ISSN
1549-3296