Journal article
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology
Abstract
The relationship between long-term cholinergic dysfunction and risk of developing dementia is poorly understood. Here we used mice with deletion of the vesicular acetylcholine transporter (VAChT) in the forebrain to model cholinergic abnormalities observed in dementia. Whole-genome RNA sequencing of hippocampal samples revealed that cholinergic failure causes changes in RNA metabolism. Remarkably, key transcripts related to Alzheimer's disease …
Authors
Kolisnyk B; Al-Onaizi M; Soreq L; Barbash S; Bekenstein U; Haberman N; Hanin G; Kish MT; da Silva JS; Fahnestock M
Journal
Cerebral Cortex, Vol. 27, No. 7, pp. 3553–3567
Publisher
Oxford University Press (OUP)
Publication Date
July 1, 2017
DOI
10.1093/cercor/bhw177
ISSN
1047-3211
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AcetylcholineAlzheimer DiseaseAmyloid Precursor Protein SecretasesAmyloid beta-PeptidesAnimalsAspartic Acid EndopeptidasesCells, CulturedDisease Models, AnimalEmbryo, MammalianEnzyme InhibitorsGene Expression RegulationGlycogen Synthase Kinase 3HippocampusHumansLearning DisabilitiesMiceMice, Inbred C57BLMice, TransgenicRNAThiazolesThyroid Nuclear Factor 1UreaVesicular Acetylcholine Transport Proteins