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The pea3 subfamily ets genes are required for...
Journal article

The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

Abstract

BACKGROUND: The PEA3 Ets transcription factor is overexpressed in the vast majority of human breast tumors and in nearly all of those of the HER2/Neu-positive subclass. PEA3 is also overexpressed in various transgenic mouse models of this disease. Whether PEA3 plays an essential role in HER2/Neu-mediated oncogenesis has heretofore not been addressed. RESULTS: Here, we report that each of the three highly related ets genes of the pea3 subfamily …

Authors

Shepherd TG; Kockeritz L; Szrajber MR; Muller WJ; Hassell JA

Journal

Current Biology, Vol. 11, No. 22, pp. 1739–1748

Publisher

Elsevier

Publication Date

November 2001

DOI

10.1016/s0960-9822(01)00536-x

ISSN

0960-9822