Journal article
Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation
Abstract
While normal kidneys are relatively sensitive to ionizing radiation (IR), renal cell carcinoma (RCC) is considered radioresistant. Carbonic anhydrase IX (CA9), an enzyme that maintains intracellular pH by carbon dioxide dissolution, is upregulated in the majority of RCC, but not in normal kidneys. Since regulation of intracellular pH may enhance radiation effects, we hypothesized that inhibition of CA9 may radiosensitize RCC. Clonogenic …
Authors
DUIVENVOORDEN WCM; HOPMANS SN; GALLINO D; FARRELL T; GERDES C; GLENNIE D; LUKKA H; PINTHUS JH
Journal
Oncology Reports, Vol. 34, No. 4, pp. 1968–1976
Publisher
Spandidos Publications
Publication Date
October 2015
DOI
10.3892/or.2015.4184
ISSN
1021-335X