Journal article
Induction of Flexibility through Protein-Protein Interactions*
Abstract
The dimerization/docking (D/D) domain of the cyclic AMP-dependent protein kinase (PKA) holoenzyme mediates important protein-protein interactions that direct the subcellular localization of the enzyme. A kinase anchoring proteins (AKAPs) provide the molecular scaffold for the localization of PKA. The recent solution structures of two D/D AKAP complexes revealed that the AKAP binds to a surface-exposed, hydrophobic groove on the D/D. In the …
Authors
Fayos R; Melacini G; Newlon MG; Burns L; Scott JD; Jennings PA
Journal
Journal of Biological Chemistry, Vol. 278, No. 20, pp. 18581–18587
Publisher
Elsevier
Publication Date
May 2003
DOI
10.1074/jbc.m300866200
ISSN
0021-9258