Journal article
Anomalous Diffusion of Proteins Due to Molecular Crowding
Abstract
We have studied the diffusion of tracer proteins in highly concentrated random-coil polymer and globular protein solutions imitating the crowded conditions encountered in cellular environments. Using fluorescence correlation spectroscopy, we measured the anomalous diffusion exponent alpha characterizing the dependence of the mean-square displacement of the tracer proteins on time, r(2)(t) approximately t(alpha). We observed that the diffusion …
Authors
Banks DS; Fradin C
Journal
Biophysical Journal, Vol. 89, No. 5, pp. 2960–2971
Publisher
Elsevier
Publication Date
November 2005
DOI
10.1529/biophysj.104.051078
ISSN
0006-3495