Journal article
Isostructural fluorescent and radioactive probes for monitoring neural stem and progenitor cell transplants
Abstract
A construct for tagging neurospheres and monitoring cell transplantations was developed using a new technology for producing luminescent and radiolabeled probes that have identical structures. The HIV1-Tat basic domain derivatives NAcGRKKRRQRRR(SAACQ)G (SAACQ-1) and [NAcGRKKRRQRRR(Re(CO)3SAACQ)G]+ (ReSAACQ-1) were prepared in excellent yields using the single amino acid chelate-quinoline (SAACQ) ligand and its Re(I) complex and conventional …
Authors
Schaffer P; Gleave JA; Lemon JA; Reid LC; Pacey LKK; Farncombe TH; Boreham DR; Zubieta J; Babich JW; Doering LC
Journal
Nuclear Medicine and Biology, Vol. 35, No. 2, pp. 159–169
Publisher
Elsevier
Publication Date
February 2008
DOI
10.1016/j.nucmedbio.2007.11.001
ISSN
0969-8051
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCells, CulturedChelating AgentsCytoplasmFluorescent DyesHeadIsotope LabelingLuminescent ProteinsMiceNervous SystemNuclear EnvelopeQuinolinesRadiopharmaceuticalsStaining and LabelingStem Cell TransplantationStem CellsTechnetiumTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedWhole Body Imagingtat Gene Products, Human Immunodeficiency Virus