Journal article
Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.
Abstract
Rodent tumor cells engineered to secrete cytokines such as interleukin 2 (IL-2) or IL-4 are rejected by syngeneic recipients due to an enhanced antitumor host immune response. An adenovirus vector (AdCAIL-2) containing the human IL-2 gene has been constructed and shown to direct secretion of high levels of human IL-2 in infected tumor cells. AdCAIL-2 induces regression of tumors in a transgenic mouse model of mammary adenocarcinoma following …
Authors
Addison CL; Braciak T; Ralston R; Muller WJ; Gauldie J; Graham FL
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 18, pp. 8522–8526
Publisher
Proceedings of the National Academy of Sciences
Publication Date
August 29, 1995
DOI
10.1073/pnas.92.18.8522
ISSN
0027-8424