Journal article
Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans
Abstract
BackgroundWhile stress and the absence of social support during pregnancy have been linked to poor health outcomes, the underlying biological mechanisms are unclear.MethodsWe examined whether adverse experiences during pregnancy alter DNA methylation (DNAm) in maternal epigenomes. Analyses included 250 African-American mothers from the Boston Birth Cohort. Genome-wide DNAm profiling was performed in maternal blood collected after delivery, …
Authors
Surkan PJ; Hong X; Zhang B; Nawa N; Ji H; Tang W-Y; Ji Y; Kimmel MC; Wang G; Pearson C
Journal
Pediatric Research, Vol. 88, No. 1, pp. 131–138
Publisher
Springer Nature
Publication Date
July 2020
DOI
10.1038/s41390-019-0512-7
ISSN
0031-3998
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAdenosine TriphosphatasesAdultBlack or African AmericanBostonCalmodulin-Binding ProteinsCardiac MyosinsCpG IslandsDNA MethylationDNA-Binding ProteinsEpigenomeEpigenomicsFathersFemaleGenome-Wide Association StudyHumansMaleMembrane ProteinsMinor Histocompatibility AntigensMolecular ChaperonesMothersMyosin Heavy ChainsOutcome Assessment, Health CarePregnancyPremature BirthRetrospective StudiesSocial ClassSocial SupportTranscription FactorsUrban PopulationYoung Adult