Journal article
MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
Abstract
BACKGROUND: Steroid-resistant asthma is a major clinical problem that is linked to activation of innate immune cells. Levels of IFN-γ and LPS are often increased in these patients. Cooperative signaling between IFN-γ/LPS induces macrophage-dependent steroid-resistant airway hyperresponsiveness (AHR) in mouse models. MicroRNAs (miRs) are small noncoding RNAs that regulate the function of innate immune cells by controlling mRNA stability and …
Authors
Li JJ; Tay HL; Maltby S; Xiang Y; Eyers F; Hatchwell L; Zhou H; Toop HD; Morris JC; Nair P
Journal
Journal of Allergy and Clinical Immunology, Vol. 136, No. 2, pp. 462–473
Publisher
Elsevier
Publication Date
August 2015
DOI
10.1016/j.jaci.2014.11.044
ISSN
0091-6749
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAsthmaBronchial HyperreactivityDexamethasoneDisease Models, AnimalEgg HypersensitivityEosinophilsGene Expression RegulationGenes, ReporterGlucocorticoidsHumansInterferon-gammaLipopolysaccharidesLuciferasesMacrophages, AlveolarMiceMice, Inbred BALB CMicroRNAsNeutrophilsOligonucleotidesOvalbuminPrimary Cell CultureProtein Phosphatase 2Receptors, GlucocorticoidSignal Transduction