Journal article
Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial
Abstract
OBJECTIVE: To identify genetic determinants of increased cardiovascular mortality among subjects with type 2 diabetes who underwent intensive glycemic therapy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
RESEARCH DESIGN AND METHODS: A total of 6.8 million common variants were analyzed for genome-wide association with cardiovascular mortality among 2,667 self-reported white subjects in the ACCORD intensive treatment …
Authors
Shah HS; Gao H; Morieri ML; Skupien J; Marvel S; Paré G; Mannino GC; Buranasupkajorn P; Mendonca C; Hastings T
Journal
Diabetes Care, Vol. 39, No. 11, pp. 1915–1924
Publisher
American Diabetes Association
Publication Date
November 1, 2016
DOI
10.2337/dc16-0285
ISSN
0149-5992
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AgedBlood GlucoseCardiovascular DiseasesCohort StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGlycated HemoglobinHumansHypoglycemic AgentsMaleMiddle AgedPolymorphism, Single NucleotideProportional Hazards ModelsRandomized Controlled Trials as TopicRisk Factors