Journal article
Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice
Abstract
BackgroundCirculating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic autoimmunity, increased emotional reactivity, enhanced expression of the histone variant macroH2A1 in the cerebral cortex, and loss of plaque/tangle pathology. Conversely, adult females display less severe …
Authors
Kapadia M; Mian MF; Ma D; Hutton CP; Azam A; Narkaj K; Cao C; Brown B; Michalski B; Morgan D
Journal
Alzheimer's Research & Therapy, Vol. 13, No. 1,
Publisher
Springer Nature
Publication Date
December 2021
DOI
10.1186/s13195-020-00745-9
ISSN
1758-9193