Journal article
Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression
Abstract
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1), a major regulator of the plasmin-based pericellular proteolytic cascade, is significantly increased in human arterial plaques contributing to vessel fibrosis, arteriosclerosis and thrombosis, particularly in the context of elevated tissue TGF-β1. Identification of molecular events underlying to PAI-1 induction in response to TGF-β1 may yield novel targets for the therapy of cardiovascular …
Authors
Samarakoon R; Chitnis SS; Higgins SP; Higgins CE; Krepinsky JC; Higgins PJ
Journal
PLOS ONE, Vol. 6, No. 7,
Publisher
Public Library of Science (PLoS)
Publication Date
2011
DOI
10.1371/journal.pone.0022896
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAortaBlotting, WesternCaveolin 1Cells, CulturedEmbryo, MammalianFibroblastsHumansImmunoenzyme TechniquesMiceMice, KnockoutMuscle, Smooth, VascularOxidation-ReductionPhosphoprotein PhosphatasesPhosphorylationPlasminogen Activator Inhibitor 1Protein Phosphatase 2CProto-Oncogene Proteins pp60(c-src)RNA, Small InterferingRatsReactive Oxygen SpeciesSignal TransductionSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1