Journal article
TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics*
Abstract
The tetracycline antibiotics block microbial translation and constitute an important group of antimicrobial agents that find broad clinical utility. Resistance to this class of antibiotics is primarily the result of active efflux or ribosomal protection; however, a novel mechanism of resistance has been reported to be oxygen-dependent destruction of the drugs catalyzed by the enzyme TetX. Paradoxically, the tetX genes have been identified on …
Authors
Yang W; Moore IF; Koteva KP; Bareich DC; Hughes DW; Wright GD
Journal
Journal of Biological Chemistry, Vol. 279, No. 50, pp. 52346–52352
Publisher
Elsevier
Publication Date
December 2004
DOI
10.1074/jbc.m409573200
ISSN
0021-9258