Journal article
A macrophage-stimulating compound from a screen of microbial natural products
Abstract
Rising rates of antibiotic resistance in bacterial pathogens is a medical crisis of global concern that necessitates the development of new treatment strategies. We have isolated a natural product with macrophage-stimulating activity from a screen of microbially produced bioactive molecules. Streptazolin increased bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Furthermore, we show that streptazolin …
Authors
Perry JA; Koteva K; Verschoor CP; Wang W; Bowdish DM; Wright GD
Journal
The Journal of Antibiotics, Vol. 68, No. 1, pp. 40–46
Publisher
Springer Nature
Publication Date
January 2015
DOI
10.1038/ja.2014.83
ISSN
0021-8820