Journal article
Tacrolimus preserves vasomotor function and maintains vascular homeostasis
Abstract
BACKGROUND: Post-transplant immunosuppression is associated with endothelial dysfunction that may lead to vasculopathy. We have previously demonstrated that cyclosporine causes vascular dysfunction. In this we study examined the effect of tacrolimus (Tac) in an identical model.
METHODS: Lewis rats (n = 8 per group) were injected with Tac (low, medium or high dose) or saline (Con) daily for 2 weeks. Segments of thoracic aorta (TAo) were assessed …
Authors
Tepperman ED; Tumiati LC; Ramzy D; Badiwala MV; Sheshgiri R; Prodger JL; Ross HJ; Rao V
Journal
The Journal of Heart and Lung Transplantation, Vol. 30, No. 5, pp. 583–588
Publisher
Elsevier
Publication Date
May 2011
DOI
10.1016/j.healun.2010.11.022
ISSN
1053-2498