Journal article
Ventilatory and Arousal Responses to Hypoxia and Hypercapnia in a Canine Model of Obstructive Sleep Apnea
Abstract
We have previously described a canine model of obstructive sleep apnea (OSA) in which sleep-wake state is monitored continuously by a computer that produces tracheal occlusion when sleep occurs. Our aim was to assess the effects of long-term application of this model on resting ventilation and on the ventilatory and arousal responses to hypercapnia and hypoxia. Five dogs were maintained on the model for 15.5 +/- 1.7 (mean +/- SE) wk, with a …
Authors
KIMOFF RJ; BROOKS D; HORNER RL; KOZAR LF; RENDER-TEIXEIRA CL; CHAMPAGNE V; MAYER P; PHILLIPSON EA
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 156, No. 3, pp. 886–894
Publisher
American Thoracic Society
Publication Date
September 1, 1997
DOI
10.1164/ajrccm.156.3.9610060
ISSN
1073-449X