Journal article
Eosinophil-derived IL-13 promotes emphysema
Abstract
The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a mouse model and to emphysema in patients with chronic obstructive pulmonary disease (COPD).A transgenic mouse model of chronic type 2 pulmonary inflammation (I5/hE2) was used to examine eosinophil-dependent mechanisms leading to airspace enlargement. Human sputum …
Authors
Doyle AD; Mukherjee M; LeSuer WE; Bittner TB; Pasha SM; Frere JJ; Neely JL; Kloeber JA; Shim KP; Ochkur SI
Journal
European Respiratory Journal, Vol. 53, No. 5,
Publisher
European Respiratory Society (ERS)
Publication Date
5 2019
DOI
10.1183/13993003.01291-2018
ISSN
0903-1936