Journal article
Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice
Abstract
The triple-transgenic (3xTg-AD) mouse strain is a valuable model of Alzheimer's disease (AD) because it develops both amyloid-β (Aβ) and tau brain pathology. However, 1-year-old 3xTg-AD males no longer show plaques and tangles, yet early in life they exhibit diverse signs of systemic autoimmunity. The current study aimed to address whether females, which exhibit more severe plaque/tangle pathology at 1 year of age, show similar autoimmune …
Authors
Kapadia M; Mian MF; Michalski B; Azam AB; Ma D; Salwierz P; Christopher A; Rosa E; Zovkic IB; Forsythe P
Journal
Journal of Alzheimer’s Disease, Vol. 63, No. 3, pp. 1191–1205
Publisher
SAGE Publications
Publication Date
2018
DOI
10.3233/jad-170779
ISSN
1387-2877
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAntigens, CDAutoantibodiesAutoimmunityDNADisease Models, AnimalFemaleGene Expression RegulationHematocritHistonesHumansMaleMiceMice, Inbred C57BLMice, TransgenicMutationNuclear ProteinsOrgan SizePresenilin-1Sex CharacteristicsSpleenT-Lymphocytestau Proteins