Journal article
Behavioural Effects of Using Sulfasalazine to Inhibit Glutamate Released by Cancer Cells: A Novel target for Cancer-Induced Depression
Abstract
Despite the lack of robust evidence of effectiveness, current treatment options for cancer-induced depression (CID) are limited to those developed for non-cancer related depression. Here, anhedonia-like and coping behaviours were assessed in female BALB/c mice inoculated with 4T1 mammary carcinoma cells. The behavioural effects of orally administered sulfasalazine (SSZ), a system xc− inhibitor, were compared with fluoxetine (FLX). FLX and SSZ …
Authors
Nashed MG; Ungard RG; Young K; Zacal NJ; Seidlitz EP; Fazzari J; Frey BN; Singh G
Journal
Scientific Reports, Vol. 7, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep41382
ISSN
2045-2322