Herpesvirus 2, Human Concept

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• A critical role for IL‐15 in TLR‐mediated innate antiviral immunity against genital HSV‐2 infection  Journal Articles
• Adaptive immune responses fail to provide protection against genital HSV‐2 infection in the absence of IL‐15  Journal Articles
• Curcumin Can Decrease Tissue Inflammation and the Severity of HSV-2 Infection in the Female Reproductive Mucosa  Journal Articles
• Delayed but effective induction of mucosal memory immune responses against genital HSV-2 in the absence of secondary lymphoid organs  Journal Articles
• Detection of a transforming fragment of herpes simplex virus type 2 in clinical specimens by PCR. The Canadian Women's HIV Study Group  Journal Articles
• Differential Responses of Murine Vaginal and Uterine Epithelial Cells Prior to and Following Herpes Simplex Virus Type 2 (HSV‐2) Infection  Journal Articles
• Differential induction of innate anti-viral responses by TLR ligands against Herpes simplex virus, type 2, infection in primary genital epithelium of women  Journal Articles
• Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface  Journal Articles
• Endometrial Epithelial Cell Responses to Coinfecting Viral and Bacterial Pathogens in the Genital Tract Can Activate the HIV-1 LTR in an NFκB-and AP-1–Dependent Manner  Journal Articles
• Estradiol Enhances Antiviral CD4⁺Tissue-Resident Memory T Cell Responses following Mucosal Herpes Simplex Virus 2 Vaccination through an IL-17-Mediated Pathway  Journal Articles
• Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway  Journal Articles
• Estradiol Regulates Susceptibility following Primary Exposure to Genital Herpes Simplex Virus Type 2, while Progesterone Induces Inflammation  Journal Articles
• FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling  Journal Articles
• G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo.  Journal Articles
• Genital HSV-2 Infection Induces Short-Term NK Cell Memory  Journal Articles
• HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection  Journal Articles
• Herpes Simplex Virus Type 2 Coinfection Does Not Accelerate CD4 Count Decline in Untreated HIV Infection  Journal Articles
• Herpes Simplex Virus Type 2 Encephalitis Presenting as Multifocal Hemorrhagic Stroke  Journal Articles
• Herpes Simplex Virus Type 2 Seropositivity Among Urban Adults in Africa  Journal Articles
• Herpes simplex virus-2 in the genital mucosa  Journal Articles
• IL-17 Production by γδ+ T Cells Is Critical for Inducing Th17 Responses in the Female Genital Tract and Regulated by Estradiol and Microbiota  Journal Articles
• Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy  Journal Articles
• Immunogenicity in mice of tandem repeats of an epitope from herpes simplex gD protein when expressed by recombinant adenovirus vectors  Journal Articles
• Immunoregulatory Functions of Interferons During Genital HSV-2 Infection  Journal Articles
• Induction of Innate Immune Responses in the Female Genital Tract: Friend or Foe of HIV‐1 Infection?  Journal Articles
• Induction of Innate Immunity against Herpes Simplex Virus Type 2 Infection via Local Delivery of Toll-Like Receptor Ligands Correlates with Beta Interferon Production  Journal Articles
• Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection  Journal Articles
• Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa  Journal Articles
• Intranasal and subcutaneous immunization under the effect of estradiol leads to better protection against genital HSV-2 challenge compared to progesterone  Journal Articles
• LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection  Journal Articles
• Lack of Effectiveness of Antiretroviral Therapy in Preventing HIV Infection in Serodiscordant Couples in Uganda: An Observational Study  Journal Articles
• Local Delivery of CpG Oligodeoxynucleotides Induces Rapid Changes in the Genital Mucosa and Inhibits Replication, but Not Entry, of Herpes Simplex Virus Type 2  Journal Articles
• Male circumcision for prevention of homosexual acquisition of HIV in men  Journal Articles
• Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model  Journal Articles
• Mucosal immunization with a recombinant adenovirus vector induces local and systemic immunity and protection from herpes simplex virus.  Journal Articles
• NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.  Journal Articles
• NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection  Journal Articles
• NK cells require antigen-specific memory CD4+ T cells to mediate superior effector functions during HSV-2 recall responses in vitro  Journal Articles
• NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection  Journal Articles
• Natural Killer Cell-Derived Interferon-γ Regulates Macrophage-Mediated Immunopathology During Viral Infection  Journal Articles
• Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination  Journal Articles
• ORIGINAL ARTICLE: Estradiol Limits Viral Replication Following Intravaginal Immunization Leading to Diminished Mucosal IgG Response and Non‐sterile Protection Against Genital Herpes Challenge  Journal Articles
• Overexpression of Interleukin-15 Compromises CD4-Dependent Adaptive Immune Responses against Herpes Simplex Virus 2  Journal Articles
• Parameters of CpG oligodeoxynucleotide‐induced protection against intravaginal HSV‐2 challenge  Journal Articles
• Prevalence and incidence of, and risk factors for, HIV-1 infection among factory workers in Ethiopia, 1997-2001.  Journal Articles
• Primary HSV-2 Infection in Early Pregnancy Results in Transplacental Viral Transmission and Dose-Dependent Adverse Pregnancy Outcomes in a Novel Mouse Model  Journal Articles
• Primary human epithelial cell culture system for studying interactions between female upper genital tract and sexually transmitted viruses, HSV-2 and HIV-1  Journal Articles
• Progesterone Increases Susceptibility and Decreases Immune Responses to Genital Herpes Infection  Journal Articles
• Proinflammatory Cytokines and Chemokines - But not Interferon-β - Produced in Response to HSV-2 in Primary Human Genital Epithelial Cells are Associated with Viral Replication and the Presence of the Virion Host Shutoff Protein  Journal Articles
• Prolonged Exposure to Progesterone Prevents Induction of Protective Mucosal Responses following Intravaginal Immunization with Attenuated Herpes Simplex Virus Type 2  Journal Articles
• Protection against Genital Herpes Infection in Mice Immunized under Different Hormonal Conditions Correlates with Induction of Vagina-Associated Lymphoid Tissue  Journal Articles
• REVIEW ARTICLE: The Role of Toll‐Like Receptor Ligands/Agonists in Protection Against Genital HSV‐2 Infection  Journal Articles
• Regional Distribution of Antibodies to Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 in Men and Women in Ontario, Canada  Journal Articles
• Stabilization of HSV-2 viral vaccine candidate by spray drying  Journal Articles
• Susceptibility of Human Female Primary Genital Epithelial Cells to Herpes Simplex Virus, Type-2 and the Effect of TLR3 Ligand and Sex Hormones on Infection1  Journal Articles
• TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway  Journal Articles
• The Anti-Inflammatory Activity of Curcumin Protects the Genital Mucosal Epithelial Barrier from Disruption and Blocks Replication of HIV-1 and HSV-2  Journal Articles
• Toll‐Like Receptor (TLR)–3, but Not TLR4, Agonist Protects against Genital Herpes Infection in the Absence of Inflammation Seen with CpG DNA  Journal Articles
• Transmission of Herpes Simplex Virus Type 2 among Factory Workers in Ethiopia  Journal Articles
• Type I Interferon Receptor on NK Cells Negatively Regulates Interferon-γ Production  Journal Articles