Journal article
Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination
Abstract
It is well established that interferon gamma (IFN-γ) production by CD4+ T cells is critical for antiviral immunity against herpes simplex virus 2 (HSV-2) genital infection. However, the role of interleukin-17A (IL-17A) production by CD4+ T cells in HSV-2 antiviral immunity is yet to be elucidated. Here we demonstrate that IL-17A plays an important role in enhancing antiviral T helper type 1 (Th1) responses in the female genital tract (FGT) and …
Authors
Bagri P; Anipindi VC; Nguyen PV; Vitali D; Stämpfli MR; Kaushic C
Journal
Journal of Virology, Vol. 91, No. 23, pp. 10.1128/jvi.01234–10.1128/jvi.01217
Publisher
American Society for Microbiology
Publication Date
12 2017
DOI
10.1128/jvi.01234-17
ISSN
0022-538X