Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family Journal Articles

abstract

• A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.

authors

• Leung, KFS
• Au, WY
• Chan, AYY
• Chan, LC
• Waye, John
• Chui, David Hing-kwei
• Ma, SK

status

• published 

publication date

• February 6, 2001

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• Adult (MeSH)
• Anemia, Hemolytic, Congenital (MeSH)
• China (MeSH)
• Family Health (MeSH)
• Female (MeSH)
• Genotype (MeSH)
• Hemoglobins, Abnormal (MeSH)
• Heterozygote (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Nuclear Family (MeSH)
• Osmotic Fragility (MeSH)
• Pedigree (MeSH)
• Phenotype (MeSH)
• Spherocytosis, Hereditary (MeSH)

published in

• International Journal of Laboratory Hematology  Journal

keywords

• Adult
• Anemia, Hemolytic, Congenital
• China
• Family Health
• Female
• Genotype
• Hemoglobins, Abnormal
• Heterozygote
• Humans
• Nuclear Family
• Osmotic Fragility
• Pedigree
• Phenotype
• Spherocytosis, Hereditary

Digital Object Identifier (DOI)

• 10.1046/j.1365-2257.2001.00349.x

PubMed ID

• 11422231

start page

• 53

end page

• 55

volume

• 23

issue

• 1