Pharmacological treatment strategies in obsessive compulsive disorder: A cross-sectional view in nine international OCD centers Academic Article uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • Objective: It is unknown what next-step strategies are being used in clinical practice for patients with obsessive–compulsive disorder (OCD) who do not respond to first-line treatment. As part of a cross-sectional study of OCD, treatment and symptom information was collected. Method: Consecutive OCD out-patients in nine international centers were evaluated by self-report measures and clinical/structured interviews. OCD symptom severity was evaluated by the Yale Brown Obsessive Compulsive Scale (YBOCS) and Clinical Global Impression–Severity Scale (CGI-S). Clinical response to current treatment was evaluated by the CGI-Improvement Scale (CGI-I ≤ 2). Results: In total, 361 participants reported taking medication; 77.6% were taking a selective serotonin reuptake inhibitor; 50% reported use of at least one augmentation strategy. Antipsychotics were most often prescribed as augmenters (30.3%), followed by benzodiazepines (24.9%) and antidepressants (21.9%). No differences in OCD symptom severity were found between patients taking different classes of augmentation agents. Conclusions: Results from this international cross-sectional study indicate that current OCD treatment is in line with evidence-based treatment guidelines. Although augmentation strategies are widely used, no significant differences in OCD symptom severity were found between monotherapy and augmentation or between different therapeutic agents.


  • Van Ameringen, Michael
  • Simpson, William
  • Patterson, Beth
  • Dell’Osso, Bernardo
  • Fineberg, Naomi
  • Hollander, Eric
  • Hranov, Luchezar
  • Hranov, Georgi
  • Lochner, Christine
  • Karamustafalioglu, Oguz
  • Marazziti, Donatella
  • Menchon, Jose M
  • Nicolini, Humberto
  • Pallanti, Stefano
  • Stein, Dan J
  • Zohar, Joseph

publication date

  • June 2014

has subject area