Journal article
A quantitative model for spontaneous bone metastasis: evidence for a mitogenic effect of bone on Walker 256 cancer cells
Abstract
A new model for the study of spontaneous bone metastasis has been developed which allows for the quantification of metastatic tumor burden and cancer cell growth rate, and which describes the progressive changes in bone morphology. Walker 256 (W256) cells or vehicle were injected into the left upper thigh muscle of male Fischer rats, which were killed 7, 10 or 14 days later. By day 7, metastases had appeared in the distal femur, in the …
Authors
Kostenuik PJ; Singh G; Suyama KL; Orr FW
Journal
Clinical & Experimental Metastasis, Vol. 10, No. 6, pp. 403–410
Publisher
Springer Nature
Publication Date
November 1992
DOI
10.1007/bf00133469
ISSN
0262-0898