Journal article
The molecular basis of emetine resistance in chinese hamster ovary cells: Alteration in the 40S ribosomal subunit
Abstract
The molecular basis of resistance to the protein synthesis inhibitor emetine has been examined in cell-free, protein-synthesizing extracts derived from normal and emetine-resistant (EmtR) mutants. We had earlier shown that protein synthesis in extracts of the mutant cells was resistant to the inhibitory action of emetin. When extracts from a wild-type and mutant cell line were fractionated into supernatant (S-100) and polyribosome fractions and …
Authors
Gupta RS; Siminovitch L
Journal
Cell, Vol. 10, No. 1, pp. 61–66
Publisher
Elsevier
Publication Date
January 1977
DOI
10.1016/0092-8674(77)90140-4
ISSN
0092-8674